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New Alzheimer’s Research: Nicotinamide Riboside Supplement Shows Promise

New Alzheimer’s Research: Nicotinamide Riboside Supplement Shows Promise

Neuroscientists at the Johns Hopkins University School of Medicine and researchers at the National Institute on Aging recently showed that supplementation with nicotinamide riboside (a NAD+ precursor) improved cognitive function in a mouse model closely resembling Alzheimer’s.

They attributed the results to the restoration of brain plasticity, a key aspect of neuronal learning and memory storage.

In addition, the NAD+ was found to protect the brain structure and some of the unfortunate changes in the brain that occur in Alzheimer’s disease.

“Our findings suggest a pivotal role for cellular NAD+ depletion upstream of neuroinflammation, pTau, DNA damage, synaptic dysfunction, and neuronal degeneration in AD.

Interventions that bolster neuronal NAD+ levels therefore have therapeutic potential for AD [Alzheimer’s Disease].”

– Hou Y, Lautrup S, Cordonnier S, et al. NAD(+) supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proc Natl Acad Sci U S A. 2018;115(8):E1876-e85.

 

The study suggests potential brain health benefits of oral supplementation of nicotinamide riboside to increase NAD+ levels.

Nicotinamide riboside is the active ingredient in Niacel which is available through this website.

Read about other benefits of Nicotinamide riboside such as

  • Metabolic and weight management support
  • Promotion of healthy aging
  • Endurance support

 

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