Supports the Body’s Natural Sleep Cycle
Sustained-release Melatonin Supports Healthy Sleep Up to 6 Hours

Melatonin-SR provides 3 mg of sustained-release MicroActive^® melatonin to promote healthy sleep.  MicroActive is an innovative, patented delivery system that offers both improved absorption and sustained release. A pharmacokinetic study of MicroActive melatonin demonstrated rapid uptake and prolonged presence in plasma up to 6 hours after a single dose. MicroActive melatonin has an initial rapid release of 40% of the active ingredient in the first hour then the remaining slowly over the next six hours. 

Melatonin is a hormone produced by the pineal gland, which regulates the body’s sleep/wake cycle. Melatonin’s primary role is regulation of the body’s circadian rhythm, endocrine secretions, and sleep patterns. Studies indicate that melatonin facilitates the onset of sleep, as well as sleep efficiency.

It’s well known that good healthy sleep resets our body and is restorative. We need it to be good quality, a sufficient number of hours (7-8 hours) each night and contain adequate phases of deep rapid eye movement REM.

Circadian Rhythm — Our Internal Clock
The circadian rhythm is like an internal 24-hour “clock” that plays a central role in when we fall asleep and when we wake up. Melatonin is sometimes referred to as the “hormone of darkness” because when it is dark, your body produces more melatonin and when it is light, the production of melatonin drops.

Being exposed to bright lights in the evening or too little light during the day can disrupt the body’s normal melatonin cycles. All the screen time on computers, smart phones, television and the like, has an impact on our melatonin production.

Melatonin levels decrease as we age. This might explain changes in sleep patterns, difficulty falling asleep, etc. as people get older.

Melatonin, the Immune System and Inflammatory Signals
Melatonin has been shown to have a protective effect if the innate immune response overreacts, can cause uncontrolled release of pro-inflammatory cytokines.

See the abstract below (though a bit technical) for other benefits of melatonin, including its strong antioxidant properties.

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Key Antioxidant Glutathione in Innovative Liposomal Form
Active Antioxidant and Liver Detoxifier 

Liposomal Glutathione is an antioxidant formula designed to protect and support cellular function. Liposomal Glutathione also offers antioxidant support for liver tissue and protection.

Liposomal glutathione is a patented formulation that can avoid breakdown in the digestive tract (intestines and liver) and get into the your cells to provide benefit to your body.

Each Softgel Contains 250 mg of Active Glutathione and 125 mg of Phospholipid Complex

Liposomal Glutathione supports antioxidant defenses and detoxification in an innovative liposomal form:

• Offers the key antioxidant glutathione in a liposomal form. Liposomal supplement formulation enables glutathione to bypass the digestive system to get to your tissues.

• Purified phosphatidylcholine delivery system offers natural liposomal formation due to the hydrophobic and hydrophilic nature of phospholipids

• Liposomal form protects glutathione bonds from the degradation that can occur in digestion

• Protects the body from free radicals to support cellular function and homeostasis

• Glutathione is found in virtually every cell of the body and plays a critical role in protein synthesis, enzyme function, transport, and cell maturation*

• Optimal levels of glutathione have been associated with physical and mental health

• Supports liver health and detoxification

• Offers antioxidant support for liver tissue protection; the highest concentration of glutathione is found in the liver

• Promotes p450 phase II conjugation pathways in the liver to support detoxification

• Maintains healthy lipid metabolism and oxidative status

• Offers the key antioxidant glutathione in an innovative liposomal form

• Supports liver health and detoxification

Active Glutathione is a Master Antioxidant and Detoxifier

Glutathione  is the most powerful antioxidant our bodies have. In its active form it protects us from free radicals and the damage they can inflict on our cells and DNA. In addition, it also plays a key role in removing toxins, including heavy metals, from our bodies.

It’s widely accepted that good health depends on minimizing oxidative stress from free radicals and keeping toxins from accumulating in the body.

Unfortunately, as we age, we make less glutathione and stressors like disease and environmental factors further tax our levels.

Roles of Glutathione in the Body

“Glutathione is generally agreed to be the most significant endogenous antioxidant, though it plays many metabolic roles beyond arresting oxidative damage.

Glutathione is important to genetic preservation via protective effects on telomeres; preserves DNA integrity; is essential for liver detoxification; recycles oxidized vitamin E;  and regulates the mechanisms essential to homoeostasis, which includes enzymatic activity, protein synthesis, gene expression, and mitochondrial integrity.

The ratio of reduced glutathione to oxidized glutathione has been documented as a noted factor in many diseases and chronic health issues.

The ability to create reduced glutathione diminishes with age. At age 40, the loss is approximately 30%, and increases to as much as 50% reduction by age 65.

Other factors, including tobacco smoke, pollution, unbalanced diet, genetic inefficiencies, and use of prescription and/or over the counter drugs (most notably acetaminophen) can further compound this loss.” — From Centre d’Enseignement et de Recherche en Nutrition (CERNh). Conducted at Centre Hospitalier de Bretagne Sud, Lorient, France. March 2013.

Manufactured by Pure Encapsulations

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Multivitamin/mineral Complex in Highly Bioavailable Forms
For men and women 18 years and older

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Foundational Nutrition, Antioxidant and Metabolic Support
Healthy Nerve Support
Lipid and Water Soluble Antioxidant

Protects Against Damage to Body’s Cells
Neutralizes Free Radicals

Multifunctional Supplement 

Alpha Lipoic acid or ALA is a naturally occurring compound that’s made in the body.

Alpha Lipoic Acid serves vital functions at the cellular level, including helping to maintain healthy glucose metabolism, supporting the nervous system and providing nutritional support for liver function and other metabolic processes.

The ability of alpha lipoic acid to modulate nitric oxide metabolite activity and to promote healthy microcirculation accounted for its ability to promote nerve cell health in two separate studies.

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Promotes Healthy Cellular Immune Response to Support Innate Immunity

Promotes Respiratory, Gastrointestinal and Immune Function

Blend of Astragalus, Biologically Standardized Andrographis, and Reishi  Mushroom Beta Glucans

• Astragalus – contains a variety of active constituents, including saponins and flavonoids, that contribute to its long tradition of immune and cytokine balance support. Studies suggest that astragalus supports NK (natural killer) cell activity, as well as IgA and IgG (immunoglobulins) levels in serum, key antibodies that play a critical role in mucosal immune defense.

• Andrographis –  the andrographis extract is standardized for andrographolide and other bioactive diterpene lactones. Research shows that supplementation with 200 mg of AP-Bio^® Andrographis for five days promoted immune function and supported respiratory comfort. It is also suggested that it helps to support macrophage (white blood cells that fight infectious agents) function.

• Reishi mushroom – offers a rich source of polysaccharides to promote cell-mediated immunity. The formula includes both reishi mushroom extract and a unique, highly-purified, reishi mushroom-derived beta 1,3/1,6-D glucan extract.

From Pure Encapsulations

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Targeted Support for MTHFR SNPs in the Methylation Pathway
Based on Nutrigenomics

Naturally occurring, universally metabolized form of folate (Metafolin® brand)

Metafolin® is chemically identical to the active folate metabolite, 5-methyl-tetrahydrofolate (L-5-MTHF). This is the predominant, naturally occurring form of folate in food.

This form of folate is directly usable by the body because it bypasses several enzymatic activation steps. Metafolin provides all of the benefits of folic acid regardless of functional or genetic variations.

The L-5-MTHF active form of folate is important for individuals with a MTHFR variation — A1298C and/or C677T. People with MTHFR SNPs may have a reduced ability to activate folic acid to the form that the body can utilize.

Genetic variations affecting activation and metabolism of supplemental folic acid are highly prevalent.

Manufactured and formulated by Pure Encapsulations, Sudbury, MA.

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Supports the Methylation Pathway

This supplement provides 50 mg. of activated B6 (pyridoxal-5-phosphate), the predominant form of circulating B6.

People with genetic variations in the CBS gene may have an up-regulation in this gene. Thus they may have an increased requirement for P-5-P.

Why P-5-P, the Activated Vitamin B6 Preferred?

P-5-P is the special form of Vitamin B6 that your body can easily utilize. It’s the activated form of B6. In fact, the other forms of B6 have to first be converted into P-5-P in order for their bodies to be able to use it.

The forms of Vitamin B6 that have to be converted into P-5-P in order to be utilized as a coenzyme are: pyridoxine, pyridoxal, or pyridoxamine.

Conversion of non-P-5-P forms of Vitamin B6 to P-5-P occurs in the intestinal absorptive cells or the liver.

But what if this conversion is not optimal? This can be the case in older adults, people with impaired liver function or those with GI issues, (e.g. celiac disease or GI inflammation).

Vitamin B6 in its active form (P-5-P) is the form that the body can most readily utilize.

Physiological Roles of Vitamin B6

Vitamin B6 plays many key roles in the body. For example Vitamin B6 is needed for:

• amino acid metabolism and neurotransmitter production and detoxification
• proper absorption of vitamin B12 and magnesium
• production of gastric acid needed for digestion and gut microbial health
• production of antibodies and red blood cells
• energy production in the liver and muscles
• metabolism of carbohydrates and fats
• maintaining sodium and potassium balance (Na:K balance regulates body fluids and promotes the healthy functioning of the nervous and musculoskeletal systems.)
• reducing pain and inflammation in early stages of carpal tunnel syndrome

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Vitamin B12 Blend for Nerve and Mitochondrial Support

Support Methylation Pathway

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Multivitamin/Mineral complex Targeting Common Genetic Polymorphisms (SNPs) to Support Daily Wellness

Foundational Support for Methylation Pathway; Based on Nutrigenomics

Why is Methylation Important?

Methylation plays many roles including neurotransmission, vitamin assimilation, DNA synthesis and gene regulation.

These functions maintain cardiovascular health, detoxification, neuroprotection, cognition, emotional wellness and cellular protection.

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Support for Healthy Liver Detoxification
Promotes Healthy Estrogen and Other Hormone Metabolism
Phase II Detox Support, May Support COMT gene SNPs

DIM Detox provides powerful support for the liver’s natural detoxification process and cellular health. It promotes healthy cell cycle function and metabolism of estrogen, dopamine, and norepinephrine.

Ingredients in DIM Detox include compounds naturally found in cruciferous vegetables (diindolylmethane) that promote phase II detoxification pathways. Cruciferous vegetables include broccoli, Brussels sprouts, cabbage and kale.

DIM Detox also contains the bioflavonoid silymarin, a support for the liver. Silymarin is naturally found in the milk thistle plant. Silymarin as well as other ingredients like alpha lipoic acid and n-acetyl-l-cysteine, act to support phase II detoxification enzyme activity in the liver and offer antioxidant support for cellular protection. In addition, taurine, glycine and methionine promote phase II detoxification pathways and healthy cell metabolism.

People with genetic variations in the COMT gene may have reduced ability to detoxify estrogen as well as the neurotransmitters dopamine and norepinephrine.

Manufactured and formulated by Pure Encapsulations, Sudbury, MA.

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