The Nutrition Supplement Dietitian https://mysupplementrd.com Janet Zarowitz, MS, RD, CDN, Registered Dietitian Nutritionist Sat, 18 Apr 2026 00:54:31 +0000 en-US hourly 1 https://mysupplementrd.com/wp-content/uploads/2021/08/msrd-favicon-jpg-webp-100x100.webp The Nutrition Supplement Dietitian https://mysupplementrd.com 32 32 Knee Pain and Stiff Joints? Here’s What Can Help https://mysupplementrd.com/knee-pain-stiff-joints-supplements-guide/ Sat, 18 Apr 2026 00:54:31 +0000 https://mysupplementrd.com/?p=15877 The post Knee Pain and Stiff Joints? Here’s What Can Help appeared first on The Nutrition Supplement Dietitian.

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If your knees have been slowing you down with stiffness in the morning, aching after a walk, that grinding feeling going up stairs — you’re not imagining it, and you’re not alone. Joint discomfort is one of the most common things my clients come to me about. The good news is there are real, practical steps you can take. Some involve what you eat and weight management. Some involve targeted supplements. Some involve regular exercise and stretching.


What You Need to Know

  • Joint pain and stiffness are often caused by the breakdown of cartilage and loss of joint-lubricating fluid — a chronic low-grade inflammatory process that progresses with age and weight gain.
  • An anti-inflammatory diet, particularly the Mediterranean diet, may help reduce joint inflammation from the inside out.
  • Glucosamine and chondroitin are naturally occurring building blocks of cartilage and joint fluid; supplementing them may help support joint comfort and cartilage health.†
  • Curcumin (from turmeric) and boswellia have extensive research for managing joint inflammation and discomfort.†
  • Cartigenix HP is a cutting edge supplement combining boswellia and celery seed extract, backed by published human trials showing improvements in joint comfort and joint flexibility and cartilage regeneration.†
  • Supplements work best as part of a bigger picture, along with food, movement, and weight management, not instead of them.

What Causes Joint Pain and Stiffness?

Joint pain usually comes down to three things: loss of cartilage, loss of synovial fluid, and inflammation. Cartilage is the smooth, rubbery cushion at the end of your bones. Synovial fluid is the thick, gel-like liquid that lubricates the joint and keeps it moving smoothly. When either one breaks down, joints become stiff, painful, and inflamed.

Osteoarthritis is the most common reason for knee and other joint pain. It’s not an autoimmune disease — it’s a wear-and-tear condition where the cartilage gradually wears down over time. Age is an unavoidable risk factor. Extra body weight speeds the process, because every pound puts several pounds of pressure on the knee joint with each step. The knee is a weight bearing joint, so osteoarthritis often shows up there before other joints.


Food for Healthy Joints and Cartilage

Before we talk supplements, I want to say this clearly: food matters. Chronic inflammation, the kind that quietly drives joint pain and stiffness, is directly influenced by what you eat every day.

What Is the Best Diet for Joint Health?

The Mediterranean diet is the dietary pattern with the most researched support for managing inflammation. It is a whole foods diet that emphasizes:

  • Fatty fish like salmon, sardines, and mackerel — rich in omega-3s, which have natural anti-inflammatory properties
  • Colorful vegetables and fruits packed with antioxidants, plant pigments and polyphenols that help neutralize inflammatory compounds, and fiber that supports a healthy gut microbiome
  • Olive oil as the primary fat — a source of oleocanthal, a compound studied for its anti-inflammatory effects
  • Whole grains, unrefined carbohydrates, legumes, nuts and seeds
  • Occasional red meat and very limited processed food and added sugars

On the other hand, ultra-processed foods, refined carbohydrates, and excess sugar can drive inflammation. This may be related to the fact that what you eat affects the gut microbiome and gut health.

How Does Gut Health Affect Joint Pain?

Did you know that there is a gut-joint axis? According to the Arthritis Foundation, the microbiome in the gut can impact osteoarthritis.

For example, excesses of pro-inflammatory gut bacteria (and low levels of beneficial bacteria), can result in intestinal permeability and consequential systemic low-grade inflammation. This inflammation can reach the joints, resulting in cartilage degradation and pain.


Supplements for Joint Pain

Glucosamine and Chondroitin: Structural Support and Building Blocks for Joint Health

Glucosamine and chondroitin are naturally occurring compounds found in healthy cartilage and synovial fluid. Your body makes them on its own, but production declines with age which is part of why joint health becomes harder to maintain over time.

Glucosamine helps build and maintain cartilage. Chondroitin acts to retain water, needed for the synovial fluid to give cartilage its shock-absorbing properties and its resistance to compression. Together, they’re among the most widely used joint support supplements; recommended by both patients and clinicians who have seen results with them.

Supplementing with glucosamine and chondroitin may support cartilage health and help maintain joint comfort, particularly for people experiencing the effects of age-related joint wear. Results tend to develop gradually — most people who notice a benefit do so after a month to a few months of consistent use. If you’re starting them, give them time.

I carry both Glucosamine and Chondroitin Sulfate  and a Glucosamine, Chondroitin, and MSM combination for clients who prefer to include MSM. MSM (methylsulfonylmethane) is a naturally occurring sulfur compound that supports healthy joint tissue and cartilage.

Curcumin and Boswellia: Targeting Joint Inflammation

If your joints are actively inflamed and painful, addressing the structural support is not enough…you also need to address the pain and inflammation.

Curcumin, the active compound in turmeric, has been studied for reducing joint pain and inflammation. It works by helping to modulate inflammatory pathways in the body. A practical note: curcumin on its own is poorly absorbed since it is a large molecule. Look for a formula that has proven bioavailability, either through phospholipid complexing (like BCM-95) or a specialized delivery system, otherwise you may not be getting the full benefit. CuraPro is a curcumin only BCM-95 product. 

Boswellia (also called Indian frankincense) is an herbal extract with a long history of use for joint and inflammatory conditions. Research shows that it supports a healthy inflammatory response in joint tissue.

Curaphen combines clinically studied curcumin with boswellia in one formula. Many of my clients notice a meaningful difference in how their joints feel within the first few days of taking it. Curaphen also comes in Curaphen Extra Strength.

Cartigenix HP: Targets Inflammation and Rebuilds Cartilage

Cartigenix HP is a supplement I’ve recently added to my practice, a plant-based formula with solid clinical backing.

It contains a proprietary blend which combines standardized Boswellia extract with wild celery seed extract from Northern India. Together these ingredients provide 13 bioactive compounds (including standardized serratol, tirucallic acids, and aplin) that work synergistically to support joint health.

The clinical research behind Cartigenix HP includes three published human trials — including two randomized, placebo-controlled studies — showing improvements in joint comfort, mobility, and cartilage support. Some participants reported noticeable improvement in as little as 15 days, with statistically significant results at 90 days.

Particularly impressive is that knee x-rays before and after Cartigenix HP show cartilage rebuilding; lab tests before and after Cartigenix HP show lower levels of inflammatory markers and higher levels of anti-inflammatory markers.† (See the Cartigenix HP product page for info on the study results).


The Takeaway: My Multi-prong Approach to Joint Health and Osteoarthritis

Supplements are one tool, not the whole toolbox. The clients I see make the most progress when they’re working on food, movement, and weight alongside any supplementation.

Which combination makes sense depends on the individual — their symptoms, their other health conditions, and what they’re already taking.

When I work with clients, I try to manage their pain while also supporting the underlying health and inflammation of the joint.

At the same time, maintaining a healthy weight is also important. Losing even a small amount of weight can meaningfully reduce the load on your knees and the pain that comes with it.

Joint health is one of those areas where there’s no single magic answer, but there’s a lot you can do. A Mediterranean-style diet, maintaining a healthy weight, staying active with low-impact movement, and the right supplement support can add up to a real difference in how you feel and how you move.

If you’d like personalized guidance on which supplements make sense for your situation, I’d love to talk. Book a free 10-minute intro call to get started.


References

Arthritis Foundation. (2023, December 7). Microbiome’s role in osteoarthritis. https://www.arthritis.org/diseases/more-about/microbiomes-role-in-osteoarthritis

Dr. Anish Desai, Dr. Parshuram Shendge, Dr. Sunaina Anand and Dr. Sreeni Nair. Clinical effectiveness and tolerability of Celery seed and Boswellia serrata extract in osteoarthritis. Int. J. Orthop. Sci. 2022;8(2):248-252. DOI: 10.22271/ortho.2022.v8.i2d.3143

Desai, A., Anand, S., Nair, S., Chorghe, P. (2024). Assessing the effectiveness and NSAIDs sparing effect of celery seeds and Boswellia serrata in osteoarthritis management. Indian Journal of Orthopaedics Surgery, 10(4), 318-323. https://doi.org/10.18231/j.ijos.2024.052

Kanthawang, T., Bodden, J., Joseph, G. B., Lane, N. E., Nevitt, M., McCulloch, C. E., & Link, T. M. (2021). Obese and overweight individuals have greater knee synovial inflammation and associated structural and cartilage compositional degeneration: data from the osteoarthritis initiative. Skeletal Radiology, 50(1), 217–229. https://doi.org/10.1007/s00256-020-03550-5

Liao, X., Chen, X., Zhou, Y., Xing, L., Shi, Y., & Huang, G. (2024). Added sugars and risk of osteoarthritis in adults: A case-control study based on National Health and Nutrition Examination Survey 2007–2018. PloS One, 19(11), e0313754. https://doi.org/10.1371/journal.pone.0313754

Limongi, F., Cilona, L., Guberti, E., Volpe, M., Maggi, S., Onder, G., Silano, M., Zanetti, M., Sieber, C., Gianfredi, V., Nucci, D., Ragusa, F. S., & Veronese, N. (2026). Efficacy of Mediterranean diet in musculoskeletal disorders: A systematic review and meta-analysis for primary and tertiary prevention featured in the Italian National Guidelines “La Dieta Mediterranea.” Nutrition, 142, 112950. https://doi.org/10.1016/j.nut.2025.112950

Messier, S. P., Gutekunst, D. J., Davis, C., & DeVita, P. (2005). Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis. Arthritis and Rheumatism, 52(7), 2026–2032. https://doi.org/10.1002/art.21139

Singhal, S., Hasan, N., Nirmal, K., Chawla, R., Chawla, S., Kalra, B. S., & Dhal, A. (2021). Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol. Trials, 22(1), 105. https://doi.org/10.1186/s13063-021-05053-7

Vaidya, N., Agarwal, R., Dipankar, D. G., Patkar, H., Ganu, G., Nagore, D., Godse, C., Mehta, A., Mehta, D., & Nair, S. (2025). Efficacy and Safety of Boswellia serrata and Apium graveolens L. Extract Against Knee Osteoarthritis and Cartilage Degeneration: A Randomized, Double-blind, Multicenter, Placebo-Controlled Clinical Trial. Pharmaceutical research, 42(2), 249–269. https://doi.org/10.1007/s11095-025-03818-2

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.


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Cancer, Chemo, and Supplements that Can Help https://mysupplementrd.com/cancer-chemo-and-supplements/ Sun, 06 Jul 2025 14:58:30 +0000 https://mysupplementrd.com/?p=15218 This is a great booklet on clinical research on dietary supplements that stop tumors, enhance chemotherapy and enable recovery. Each chapter contains many references to clinical research studies on cancer...

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Cancer Chemo and Supplements that Help

This is a great booklet on clinical research on dietary supplements that stop tumors, enhance chemotherapy and enable recovery.

Each chapter contains many references to clinical research studies on cancer cell responses to supplements like:

  • Andrographis
  • Berberine
  • Curcumin
  • French Grape Seed Extract OPCs.

Research presented in the booklet includes these supplements on their own, others as adjuncts to chemotherapy and some on chemotherapy alone.

In addition to improving the efficacy of chemotherapy drugs, studies show which supplements can reduce chemo resistance.

Read the Entire Booklet from InfoMedica – “Cancer, Chemo and Supplements that Help”

NOTE: Before using any of these supplements, speak with your oncologist. You might also want to share this booklet with your doctor, especially since it has many scientific references to original research papers.


Nutrition Consultations for Cancer Patients

When working with cancer patients, I consider nutrition supplements that may be complementary for each client’s cancer diagnosis and overall health, without interfering with their cancer treatments.

Some supplements have demonstrated the ability to directly fight the cancer, others boost the body’s own natural defenses (such as medicinal mushrooms) and others address side effects of treatment or nutritional insufficiencies.

I am hoping that the research expands to study supplements used in conjunction with immunotherapies, PARP inhibitors, and other therapies that follow chemotherapy or radiation.

That said, my nutrition recommendations need to be cleared by the patient’s oncologist as he or she is ultimately responsible for their medical care.


**Statements about supplements made on this website have not been evaluated by the United States Food and Drug Administration and products are not intended to diagnose, cure, treat or prevent any disease. Janet Zarowitz, MS, RD, CDN, does not advise patients through the material contained on this Web site. This website is for informational purposes only and is not intended as a substitute for advice from your physician. You should consult with your physician before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem.


 

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Serum DAO Helps Diagnose Histamine Intolerance https://mysupplementrd.com/serum-dao-may-help-diagnose-histamine-intolerance/ Fri, 14 Feb 2025 11:00:28 +0000 https://mysupplementrd.com/?p=5792 The post Serum DAO Helps Diagnose Histamine Intolerance appeared first on The Nutrition Supplement Dietitian.

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Blog Update: It can be frustrating for many clients trying to understand the root cause of their often multi-system symptoms, because a test for histamine intolerance is not clear cut. However, an experienced practitioner can help you evaluate your symptoms and health history to diagnose histamine intolerance.

As and Integrative and Functional Registered Dietitian Nutritionist, I work with the diagnosis and develop personalized dietary, supplement and lifestyle protocols to support healthy histamine levels and symptoms. (Original blog was posted in 2017.)


In a 3 1/2 year study, researchers determined that DAO (diamine oxidase) activity in serum along with a detailed history might be useful for a diagnosis of histamine intolerance.

Their results also showed the benefit of histamine-free diet. After implementing the diet, a majority of histamine related symptoms disappeared and DAO activity in serum increased.

Serum diamine oxidase (DAO) activity as a diagnostic test for histamine intolerance” Clinical Translational Allergy. 2011; 1(Suppl 1): P115.
Authors: Ema Music,  Mira Silar, Peter Korosec, Mitja Kosnik,and Matija Rijavec

Study Excerpt:

Histamine intolerance is mainly caused by an imbalance of histamine intake and the capacity for histamine metabolism and degradation. The main enzyme for metabolism of ingested histamine is diamine oxidase (DAO). Determination of DAO activity in serum might be useful for differential diagnosis of histamine intolerance.

Over the 3.5-year-long period we have recruited 316 patients with suspicion of histamine intolerance and excluded food allergy together with 20 healthy controls. Serum DAO activity was measured with Enzyme immunoassay for the quantitative determination of histamine-degradation activity by DAO in serum. Twenty patients with histamine intolerance and highly reduced initial activity of serum DAO (<40 HDU/ml) went to a histamine-free diet and after 6 to 12 months of histamine-free diet all clinical parameters and serum for determination of DAO activity were taken again.

We found that DAO activity was significantly lower in patients than in healthy control subjects (P<0.0001). Furthermore, 54 patients had highly reduced activity of DAO (<40 HDU/ml). The main symptoms involved the skin, gastrointestinal tract, respiratory system and eyes. In all 20 patients after the histamine-free diet the main clinical symptoms typical for histamine intolerance have disappeared. Furthermore, the measured values for activity of serum DAO have increased significantly (p<0.0001).

We can conclude that determination of DAO activity in serum is a useful diagnostic tool, together with detailed history to differentiate between food allergy and histamine intolerance.

It should be performed in suspected patients with symptoms like headache, tachycardia, urticaria, pruritus, diarrhea and hypotension, where food allergy was excluded. Furthermore, our results showed the benefit of histamine-free diet, since after the diet majority of histamine related symptoms have disappeared as well as the DAO activity in serum has increased.


Histamine intolerance may develop when the body doesn’t have the capacity to fully metabolize and degrade histamine load in the body.

Whether it’s from the histamines found in or triggered by food or medications, or from other environmental factors, this imbalance overwhelms the body.

The body produces DAO (diamine oxidase), the main enzyme that metabolizes ingested histamine, though often not in adequate amounts.

I have developed a protocol for histamine intolerance which includes a DAO enzyme supplement — Histamine Digest, in particular for clients experiencing related GI distress. I also work with clients to support a secondary pathway through which histamines are degraded.

Read my blog, Do You Have a Histamine Intolerance? Nutrition Can Help!


 

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GLP-1 — The Un-Hunger Hormone https://mysupplementrd.com/how-to-naturally-boost-glp-1-un-hunger-hormone-with-diet-for-weight-loss/ Fri, 26 Apr 2024 17:05:44 +0000 https://mysupplementrd.com/?p=14016 For so many, losing weight and/or maintaining a healthy weight remains a challenge. Scientists recognize that maintaining a healthy body weight is more complicated than just calories in, calories out....

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For so many, losing weight and/or maintaining a healthy weight remains a challenge.

Scientists recognize that maintaining a healthy body weight is more complicated than just calories in, calories out. They are studying why in modern society hunger/satiety signals are malfunctioning, how lack of sleep, excess stress and environmental toxins promote obesity, and how the human body is hard-wired to crave certain types of food.

In pre-modern days, when food was more scarce and never guaranteed, it was an evolutionary and survival advantage to eat as much as one could whenever food was available. (After all, access to food made it more likely that you would survive and pass on your genes to future generations!)

But today, in our urban societies we can access food practically round-the-clock, with little to no energy or effort, whether it’s from Starbucks, take-out, a supermarket, or just taking a few steps to our refrigerator.


 Weight loss through diet and gut healthObesity, Health Concerns and Ozempic

Obesity isn’t just about weight either, it is also associated with: 

  • bodily inflammation 
  • insulin resistance (pre-diabetes) 
  • increased risk of medical conditions like osteoarthritis
  • increased risk of GERD
  • increased risk of metabolic disorders
  • increased risk of heart disease 
  • increased risk of sleep apnea. 

To help address the obesity epidemic, scientists are developing medications like Ozempic (semaglutide).

Ozempic supports weight loss by mimicking the body’s natural GLP-1 hormone which curbs our appetite, reduces food cravings and helps us feel full.


What is the Mechanism Behind GLP-1, the “Un-hunger” Hormone? 

GLP-1 is a signaling hormone that tells your brain that you are satiated and not hungry.

Your body naturally produces GLP-1 in the gut, but as you age your body produces less of it. Some scientists think decreased secretion of GLP-1 may be contribute to the development of obesity.

This is how GLP-1 works to support weight loss:

  • When you eat, your body releases GLP-1 hormone.
  • GLP-1 signals your pancreas to make and release insulin, reducing blood sugar levels.
  • GLP-1 hormone also slows down stomach emptying, slowing down how quickly food moves from your stomach into the intestine.
  • When your stomach remains full, GLP-1 stimulates nerves inside your gut who then send messages to your brain about being and feeling full.
  • When appetite are cravings are reduced, it helps many people maintain a healthy weight.

Ozempic has been recommended by many doctors and helped many people manage their weight, blood sugar levels and metabolic disorders. That said, even if it were available to them, many people choose not to take an injectable medication in order to lose weight.

Is there a way to support natural GLP-1 levels through diet?
Is medication the only answer?


Plant Fiber: The Natural GLP-1 Booster

The good news is that by eating more fiber, especially soluble fiber, you can naturally increase GLP-1 hormone levels, thus supporting weight loss.1

Eating more fiber helps the normally short-lived GLP-1 stick around longer, making its benefits more potent. (GLP-1 gets degraded within a matter of minutes!)

Fiber then moves through the small intestines largely unchanged (as our bodies don’t break down fiber).
Hours after you first ate, when the fiber next gets to the large intestine/colon, bacteria (gut microbiome) ferment and break down the fiber into smaller molecules.

These smaller molecules created by gut microbes feasting on fiber, trigger the release of a second boost of GLP-1 plus another hormone PPY (peptide YY) that decreases the appetite.

This second boost of GLP-1 and PYY, hours after your meal, can help you feel satiated for longer periods of time between eating.


Soluble Fiber, the Preferred Type of Fiber to Increase GLP-1, Feel Fuller Longer

If you are looking to boost your GLP-1 levels, aim to include more servings of plant foods in your diet and be sure to include foods high in soluble fiber. (Read below for more on Food Sources of  Soluble Fiber to Boost GLP-1.)

Soluble fiber easily dissolves in water and breaks down into a gel-like substance in the colon. Soluble fibers are the type of fiber that feed the gut bacteria that initiate generation of more GLP-1.

All fiber comes from plant foods, not animal products. Shift your meals and snacks to be proportionately more plant-centric and you’ll naturally raise your fiber intake!

You don’t have to count grams of soluble fiber in your diet, but make it a point to eat more servings of plant foods each day. Start by adding one additional serving of a fiber-rich food such as vegetables, fruit, nuts, seeds or beans each day and build up from there. 

Most Americans don’t eat enough total fiber. The recommended amount of total dietary fiber per day is 25-30 grams of fiber and most Americans eat only about 15 grams of fiber daily.)

(Insoluble fiber, sometimes called roughage, does not dissolve in water and remains intact as food moves through the gastrointestinal tract. Insoluble fiber supports healthy elimination. Both types of fiber are beneficial for your overall health but play different roles.)


The Natural GLP-1 Boost Formula = Diet High in Soluble Fiber + Healthy/Diverse Gut Microbiome

Besides eating a diet with more soluble fiber you also need to have a healthy and diverse microbiome in the gut to naturally produce GLP-1 for you. The gut bacteria act upon and ferment the soluble fiber which in turn supports the natural production of GLP-1!

The good news is that eating more plant foods with fiber (especially colorfully pigmented ones rich in polyphenols) will naturally support a more diverse and robust gut microbiome. And, eating probiotic rich foods like yogurt, kefir, fermented vegetables, miso, etc will further enrich the gut microbiome.

Many of my clients also take a clinically studied probiotic supplement like MegaSporeBiotic to supports a healthy gut microbiome as well.


Key Takeaways: The Natural GLP-1 Boost Formula

Many people, including many of my clients, are looking for natural weight loss supports including alternatives to taking semaglutide.
I always start with optimizing the diet and supporting their gut microbiome.

To support weight loss, you can naturally boost your own production of the un-hunger hormone GLP-1 with the natural GLP-1 Boost Formula: 

  • Eat more plant foods (the more variety the better), especially those that are good sources of soluble fiber 
  • eat fermented foods rich in probiotics, and
  • support the gut microbiome further with a with a probiotic like MegaSporeBiotic.

Resources

Excellent Sources of  Soluble Fiber to Boost GLP-1

  • Legumes and Seeds: Beans (all types), green peas, lentils, soy, nuts and seeds (almonds, chia seeds flaxseeds, peanuts, pumpkin seeds)
  • Grains: barley, corn, oats, quinoa, rice, rye, wheat
  • Fruits: most fruit, especially apples, bananas, berries, dried figs, oranges and other citrus fruit, pears, plantains, plums, prunes
  • Vegetables: many vegetables especially asparagus, avocados, beets, carrots, broccoli, Brussels sprouts, cassava, ginger, green beans, Jerusalem artichokes, kale, pumpkin, radish, root tubers, root vegetables (sweet potatoes, onions), taro, turnips, white potatoes, winter squash, yam, zucchini
  • Aim to eat 30 different plant foods each week!!

News Article

1 (Less snacking, more satisfaction: Some foods boost levels of an Ozempic-like hormone)
From NPR.ORG — October 30, 2023, by Michaeleen Doucleff


GLP-1 Activating Nutrition Supplements

In addition to helping clients with The Natural GLP-1 Boost Formula, I am also now working with some exciting research-based GLP-1 activating nutrition supplements.

Learn more about these exciting clinically researched GLP-1 Activators:
Calocurb  and Pendulum GLP-1 Probiotic Pro.


 

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Histamine Digest PureMAX Offers Another Choice for Histamine Clearance!! https://mysupplementrd.com/histamine-digest-puremax-offers-pure-dao-choice-for-histamine-clearance/ Wed, 13 Mar 2024 01:50:02 +0000 https://mysupplementrd.com/?p=13233 UPDATED 3/13/2024 Original blog was updated to reflect the new Histamine Digest PureMAX formulation and bottle image; HDU (histamine digesting units) in Histamine Digest PureMAX increased to 40,000 from 30,000...

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UPDATED 3/13/2024
Original blog was updated to reflect the new Histamine Digest PureMAX formulation and bottle image; HDU (histamine digesting units) in Histamine Digest PureMAX increased to 40,000 from 30,000 per capsule. 

DAO (Diamine Oxidase) is the enzyme that neutralizes histamine in the digestive tract. Taking the enzyme prior to eating high histamine foods and beverages helps the body break down the histamines.

Research supports that this can be extremely helpful for people with histamine intolerance and can help manage unpleasant GI or other symptoms.

People who have difficulty balancing histamine levels in their body or histamine intolerance (also known as HIT) might get annoying reactions like stuffy nose, red eyes, itchy skin or hives.

Other common symptoms are gastric hypersecretion manifested with stomach pain (especially when eating), diarrhea, nausea and migraines.


Two Formulations of Histamine Digest Are  Available on my Website Now:
Original Histamine Digest and Histamine Digest PureMAX

How do you know which DAO supplement is best?

Histamine Digest PureMAX is designed for those with multiple sensitivities and higher Diamine Oxidase (DAO) needs. The Histamine Digest PureMAX capsule only contains DAO; it does not contain Vitamin C or Catalase enzyme (found in the regular Histamine Digest). Very sensitive individuals who react to these additional ingredients can benefit from Histamine Digest PureMAX.

While the vast majority of my clients do very well with the original Histamine Digest, having the pure form of DAO (PureMAX) is a great option.


Comparing Histamine Digest and Histamine Digest PureMAX

Omne Diem Histamine Digest with DAOgest with 30,000 HDU 120 countHistamine Digest

  • 30,000 HDU/4.2 mg  (Histamine Digesting Units)
  • Contains Vitamin C and Catalase (breaks down hydrogen peroxide).
  • Other ingredients: microcrystalline cellulose, vegetarian capsule (hypromellose, gellan gum), silicon dioxide (silica)
  • 60 or 120 count

Omne Diem Histamine Digest PureMAX DAO 40,000 HDU

 

 

 

 

Histamine Digest PureMAX

  • 40,000 HDU/4.8 mg (Histamine Digesting Units)
  • Now with 40,000 HDU, due to advancements in the extraction and manufacturing process.
  • Other ingredients: microcrystalline cellulose, vegetarian capsule (hypromellose, gellan gum)
  • 60 count

Histamine Digest and Histamine Digest PureMAX
DO NOT contain: wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.


Research Shows Diamine Oxidase Supplementation Improves Symptoms in Patients with Histamine Intolerance 

“All symptoms improved significantly during the [4 week] oral supplementation of DAO. During the follow-up period, without DAO supplementation, the symptoms sum scores increased again. The symptom intensity score was reduced for all symptoms. We have demonstrated, a significant reduction of every HIT-related symptom and its intensity due to DAO oral supplements.” — Read the full study.


A second study also concluded that people who exhibited a histamine intolerance, the majority of whom had lower serum DAO levels, benefited from DAO supplementation.

Excerpt:

Intolerance to various foods, excluding bona fide coeliac disease and lactose intolerance, represents a growing cause of patient visits to allergy clinics. Histamine intolerance is a long-known, multifaceted clinical condition triggered by histamine-rich foods and alcohol and/or by drugs that liberate histamine or block diamine oxidase (DAO), the main enzyme involved in the metabolism of ingested histamine. Histamine limitation diets impose complex, non-standardized restrictions that may severely impact the quality of life of patients.

We found that 10 out of 14 patients had serum DAO activity<10 U/mL, which was the threshold suggested as a cutoff for probable histamine intolerance.

Moreover, 13 out of 14 patients subjectively reported a benefit in at least one of the disturbances related to food intolerances following diamine oxidase supplementation.

Int J Immunopathol Pharmacol. 2016 Mar;29(1):105-11. doi: 10.1177/0394632015617170. Epub 2015 Nov 16., Manzotti G, Breda D, Di Gioacchino M, Burastero SE


Doesn’t the Body Make DAO Naturally?
Yes, your body naturally makes the DAO enzyme in your intestinal mucosa cells.

However, you can have low DAO enzyme activity for many reasons, including poor gut health and inflammatory GI diseases that affect the integrity of the gut lining.

Typically as we age, we also naturally make less DAO.

Both Histamine Digest and Histamine Digest PureMAX DAO supplements are designed to boost DAO levels in the body.


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Confused about Histamine Intolerance vs Allergy? https://mysupplementrd.com/confused-about-histamine-intolerance-vs-allergy/ Mon, 22 Jan 2024 07:23:03 +0000 https://mysupplementrd.com/?p=13580 Histamine Intolerance is Not the Same as Allergy! Let Me Tell You Why! As an integrative and functional nutritionist with special expertise in Histamine Intolerance, I’d like to tell you...

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Histamine Intolerance is Not the Same as Allergy! Let Me Tell You Why!

As an integrative and functional nutritionist with special expertise in Histamine Intolerance, I’d like to tell you about Histamine Intolerance and clear up misconceptions.


What is Histamine Intolerance? What are Histamines? What are Mast Cells?

Histamine Intolerance is when there is an imbalance in the amount of accumulated histamine in your body as compared with your body’s capacity to break it down. Histamine Intolerance is also known as HIT. Histamines are chemicals largely produced by a type of white blood cells called mast cells.

Histamines are a key part of your immune system and have a vital role in digestion, sleep, and immune defense. Mast cells have the important job of storing and releasing histamines, however, they sometimes they overreact. When you have a disequilibrium of histamines in your body, it can unleash a cascade of symptoms.

(Mast Cell Activation Syndrome also known as MCAS, is an inappropriate release of ALL mast cell mediators, histamines being just one among them. Histamine Intolerance falls within the larger category of MCAS.)

Histamine Intolerance symptoms are often delayed (unlike allergies), and may take time to manifest. As histamines travel throughout the body through the bloodstream, virtually any part of the body can present with symptoms, from runny nose and itchy eyes, to diarrhea and gastric reflux, to migraine headaches and sleep disorders, to heart arrhythmias and high or low blood pressure, to painful menstrual periods and more!


Clearing Up the Confusion Between Histamine Intolerance and Allergy

One reason for the confusion and difficult diagnosis is that many common symptoms of Histamine Intolerance resemble common allergy symptoms. Histamine Intolerance and some allergic reactions may present similarly. That’s because many allergy symptoms are the result of histamine activity!

As I explain later in this post, tests done by the allergy MD (immunologist) look for a response to a particular antibody and in Histamine Intolerance there is no antibody response!

So when the doctor says, “you are not allergic to XYZ,” it doesn’t mean that your reaction to XYZ isn’t real. It just may be something else, like Histamine Intolerance. which should be explored.

According to the Cleveland Clinic, experts estimate that about 1 in 100 people have Histamine Intolerance. However, since Histamine Intolerance symptoms present differently in each person, the diagnosis of Histamine Intolerance is easily missed. It’s likely that Histamine Intolerance is even more common  than 1/100 people.


What are Common Symptoms of Histamine Intolerance?

Symptoms of Histamine Intolerance include:

  • Symptoms similar to allergies: runny nose, nose congestion, red and itchy eyes, itchy skin, hives, eczema, asthma, flushing
  • Digestive Challenges: diarrhea, nausea, bloating, cramps, gastric reflux
  • Nervous System: migraine headaches, fatigue, anxiety, brain fog, sleep disorders
  • Cardiovascular Impacts: heart arrhythmia, low blood pressure, high blood pressure
  • Women’s Health: painful, heavy menstrual periods

At first glance, many of these symptoms might not appear to be related, but I look for patterns and find that they often are related!


What is a True Allergy (IgE mediated)?
When you go to the allergy doctor, he or she tests for true allergies (IgE mediated). Allergy tests typically look for specific antibodies your immune system produces when it encounters a trigger.

When IgE allergy antibodies are the cause of the reaction to a food, for example, the immune system typically responds almost immediately. The signs and symptoms usually occur within minutes of ingestion, making it much easier to identify the trigger.  (An example of this is a peanut allergy.)

Symptoms may include itchy watery eyes, sneezing, runny nose, hives, rashness or redness of the skin, vomiting and in more severe reactions, anaphylaxis.

Why Allergy Tests Don’t Diagnose Histamine Intolerance (HIT)
Even though symptoms of Histamine Intolerance may be similar to allergy symptoms, Histamine Intolerance doesn’t involve antibodies so they are not picked up on the allergy tests.

Also, the onset of symptoms from Histamine Intolerance is usually delayed…hours, sometimes even days, making it much more challenging to identify the triggers.


What is the Histamine “Bucket”?histamine bucket
The histamine bucket refers to each individual’s capacity to handle histamine. When your bucket fills and/or doesn’t drain sufficiently, and then overflows, a person can become symptomatic.

Think of a bucket that’s overflowing or a bathtub that’s not emptying fast enough so the water spills onto the floor, causing a problem. Histamine Intolerance is about keeping histamines in balance. Histamine Intolerance is a functional imbalance.

Histamine Intolerance is when the cumulative amount of histamines in your body (both what you take in through food and what your body produces) is out of balance with your body’s ability to break down histamines. Since there are many variables that increases histamines, and it’s a cumulative effect, what might trigger you one day (think a particular food), may not trigger you another day!


What Are Some of the Causes of Histamine Intolerance?

Food Triggers. (Certain foods can trigger a histamine reaction in more than one way.)

  1. Some foods contain high levels of histamines,
  2. Some foods cause histamine to be released within the body,
  3. Other foods block the enzyme DAO. DAO is the enzyme that degrades or breaks down histamine in the gut.

Alcohol (a big trigger), leftover foods, aged cheeses, fermented products, smoked fish, cured foods, overripe fruit, deli meats, fish (unless it’s extremely fresh), are foods high in histamine and can overfill your the histamine “bucket.”

Medication Triggers. Some medications release histamine or inhibit the DAO enzyme that degrades histamine. These include some antibiotics, anesthetics, opioids, aspirin, NSAIDS, excipients, hormones.

Poor Gut Health. Underlying gut issues and infections can also play a role in causing Histamine Intolerance.

Unhealthy Lifestyle. Stress, poor sleep, smoking all contribute to Histamine Intolerance.

Environmental Triggers. Pollen dust, mold animal dander, pesticides, smog, pigments in makeup, perfumes, radiographic dyes can all trigger histamine release.

Genetic Predisposition. There can be a genetic predisposition to Histamine Intolerance, in particular to have less potential of making the histamine degrading enzyme, DAO.

I do the “detective” work to help identify and remove your personal triggers of histamine intolerance.


Nutrition Tools and Other Treatments for Histamine Intolerance: How to Bring the Histamine”Bucket” Back into Balance
    • Low Histamine Diet: Identifying and limiting triggers through a low-histamine diet and food diary can significantly reduce symptoms. I work with clients to reduce high histamine foods and eat a low histamine diet to keep the “bucket” from overflowing with too much histamines.
      I focus on limiting High Histamine Foods like alcoholic beverages, aged, fermented, cured and smoked products, without overly restricting the diet.But did you know that foods increase in histamine levels as they ripen (think overly ripe fruit), or sit in the refrigerator as leftovers, or sit in supermarket prepared food deli areas for a few days?  So the same food freshly made may not trigger a reaction, but it might trigger a reaction after sitting in your home refrigerator or in the store refrigerated section for two or three days! That said, a typically low histamine food can become a high histamine food (and trigger a reaction) when it’s less fresh, leaving the individual totally perplexed.In addition, packaged or processed foods may contain histamine-triggering food additives that would not be present in a homemade version or another brand of the same food. When I work with clients we look at the ingredients in detail to determine any suspect triggers.
    • Blood Test for Food and Food-Chemical Sensitivities: If reducing high histamine foods is not enough to relieve symptoms, I also offer testing to uncover hidden food sensitivities that may be contributing to your histamine release.Using the results of the test which identifies your triggers, I design a LEAP eating plan. LEAP is a custom anti-inflammatory eating plan and nutrition counseling program based on the Mediator Release Test (MRT). It is a scientifically based several phase diet that removes identified food and chemical triggers so your immune system can calm down, and then helps you reintroduce safe foods.
    • DAO Enzyme and Other Nutrition Supplements for Histamine Intolerance: Targeted nutrition supplements are a great tool for helping to stabilize the cells from releasing as much histamine, helping to keep the “bucket” below the “fill line.”In addition, there are supplements that support the two pathways that break down histamines in the body, helping to keep the histamine “bucket” from overflowing. The main pathway in the gut is DAO (Diamine oxidase) which can be taken as a supplement. The second pathway in the other parts of the body is HNMT which requires several nutrition cofactors to operate optimally.
    • Restore Gut Health for Histamine Intolerance: I work with clients to heal their gut lining and support a healthy, balanced, and diverse microbiome to maintain a healthy gut lining, reduce inflammation and keep histamine levels in check.
    • Changing Lifestyle Makes a Difference with Histamine Intolerance: We discuss ways to help manage stress, optimize sleep, and avoid smoking – all factors can aggravate your histamine response.

Key Takeaways for Managing Histamine Intolerance

Histamine Intolerance (HIT) and allergy are commonly confused, but understanding the distinct players, such as DAO and HNMT enzymes and mast cells, is crucial. Unlike allergies, HIT is a functional imbalance where the histamine “bucket” overflows, leading to delayed symptoms. Standard allergy tests are ineffective for HIT.

    • Identify Your Own Histamine Intolerance Triggers: I work with clients to start learning their trigger foods that may fill their histamine “bucket.”  We start by keeping a food diary, and then may go on to an elimination diet, or get a food sensitivity test for deeper insights. I am a Certified LEAP Therapist (CLT) and Functional Registered Dietitian Nutritionist, trained to evaluate the MRT food sensitivity test and implement the immune calming diet.
    • Build a Stronger “Bucket” to Keep Your Histamines in Balance: Heal your gut lining, support your microbiome, and prioritize sleep and stress management to bolster your body’s natural histamine processing abilities.
    • Tailor Your Strategies for Keeping Histamine at a Good Level: The right tools for your “bucket” might include a low-histamine diet, DAO enzyme supplements, gut health supplements, and individual lifestyle adjustments. I work with clients to help them listen to your bodies and personalize strategies to find what works best for each individual.

How I Can Help You If You are Having Histamine Intolerance Symptoms

1. SHOP Top Recommended Supplements for Histamine Intolerance

2. Schedule an Appointment or MRT Food Sensitivity Test
Contact Me for Personalized Guidance on Managing Your Histamine Intolerance (HIT). Histamine Intolerance can present in many ways. It’s best to work with a healthcare practitioner like myself who is experienced and has a track record with Histamine Intolerance.

3. Learn More About My Approach to Managing Your Histamine Intolerance Symptoms

Take control of your histamine journey. Histamine Intolerance doesn’t have to control your life. By understanding your triggers, implementing the right changes, and adopting a holistic approach to your health, you can achieve balance and experience a life free from uncomfortable symptoms.

Remember, you’re not alone in this journey. As your certified LEAP Therapist and Functional Registered Dietitian Nutritionist, I’m here to guide and support you every step of the way.  Ready to take control of your health and reclaim your life?

Contact me today to schedule a consultation and learn more about how LEAP and a personalized nutrition plan can help you manage your Histamine Intolerance (HIT) or Mast Cell Activation Syndrome (MCAS).


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Multivitamin Improves Memory in Older Adults, Study Shows https://mysupplementrd.com/multivitamin-improved-memory-older-adults/ Mon, 23 Oct 2023 15:51:46 +0000 https://mysupplementrd.com/?p=13414 Taking a daily multivitamin supplement can slow age-related memory decline, finds a large study led by researchers at Columbia University and Brigham and Women’s Hospital/Harvard. The study showed that the...

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Taking a daily multivitamin supplement can slow age-related memory decline, finds a large study led by researchers at Columbia University and Brigham and Women’s Hospital/Harvard.

The study showed that the aging brain may be more sensitive to nutrition than realized.


Just as the Body Ages, So Too Does the Brain Age

Researchers tested cognitive and memory function in more than 3500 adults, aged 60 and over, comparing those who took a daily multivitamin vs a placebo.

Results were significant. Even after the first year, memory improved for people taking a daily multivitamin vs. those taking a placebo. The improvement was sustained over the three-year study period during which they continued to take the multivitamin.

Researchers estimated the improvement in those taking the daily multivitamin to be equivalent to about three years of age-related memory decline. The improved effect was more pronounced in those with underlying cardiovascular disease.

Does It Matter Which Multivitamin You Take?

This study used Centrum Silver, which has over two dozen vitamins, minerals, and other nutrients. All multivitamins differ in their formulations. They vary in the specific vitamins and minerals they contain, the forms and dosages of the nutrients.

My “go-to” multivitamin is Thorne Basic Nutrients 2/Day, as an adjunct to a good diet.Thorne Basic Nutrients 2/day

Thorne Basic Nutrients 2/Day contains vitamins in their bioactive/readily usable forms, minerals that are highly absorbable and many nutrients in the forms that occur in nature.

Thorne Basic Nutrients 2/Day contains nutrients not found in most multis, like vitamin K2 (supports heart and bone health), nutrients for macular and retinal health, vitamin D3 and methylated B vitamins and natural forms of vitamin E.

Taken two per day (one in AM and one in PM), the water soluble vitamins stay in a steady state in the body throughout the day and night.


Is Any One Particular Nutrient Responsible for the Cognitive Improvement?

In this study, the researchers did not look at whether any specific component of the multivitamin supplement was linked to improvement in memory.

Researchers believe that the multivitamins may work by providing micronutrients that enhance function of the hippocampus area of the brain.  This is the second large study conducted by the researchers to show that memory improved in older adults who took daily multivitamins.

Double blind research studies on multivitamins are rare. That’s because the studies are very expensive to do.

This study was funded by the National Institutes of Health and also by Mars Edge, a division of Mars, which makes candy, pet food and other products; and Pfizer and Haleon, both makers of multivitamins.


Can’t I Get Enough Nutrients Through Food?

Because of the state of the current food supply, and because very few individuals eat the recommended servings of fruits and vegetables, many nutrition experts (including myself) agree that a multivitamin/mineral supplement should be taken daily. It’s kind of a nutrition “insurance” for the essential nutrients to be consumed on a daily basis.

Even the Journal of the American Medical Association – not usually known as a supporter of nutritional supplements – suggests that everyone should take a multi-vitamin/mineral supplement (JAMA 2002;287:3127-3129).


 

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Dr Kristine Burke Explains Arterial Glycocalyx and Arterosil HP https://mysupplementrd.com/endothelial_glycocalyx_arterosil_dr_burke/ Wed, 06 Sep 2023 20:42:14 +0000 https://mysupplementrd.com/?p=13253 The post Dr Kristine Burke Explains Arterial Glycocalyx and Arterosil HP appeared first on The Nutrition Supplement Dietitian.

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Kristine Burke, MD describes the importance of the endothelial glycocalyx, a micro-thin protective inner lining of blood vessels  throughout the body.

Dr. Burke uses Arterosil HP in her clinical practice to help provide the building blocks for the endothelial glycocalyx. Arterosil HP has been scientifically shown to protect the endothelial glycocalyx.

The natural ingredients in Arterosil HP feature the extract of a rare seaweed (Monostroma nitidum) and 22 fruits and vegetables and green tea.

The health of all blood vessels, from the largest arteries to the tiniest capillaries is essential to your overall cardiovascular health.

The highly dynamic endothelial glycocalyx needs ongoing support as it can be damaged by systemic inflammation, oxidative stress, a high sugar diet, diabetes, high blood pressure, physical inactivity, stress, aging, disease, smoking and air pollution.

Watch Dr. Burke discuss Arterosil HP in the video below.


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Introduction to the Endothelial Glycocalyx https://mysupplementrd.com/introduction-to-the-endothelial-glycocalyx/ Wed, 06 Sep 2023 15:03:50 +0000 https://mysupplementrd.com/?p=13279 The post Introduction to the Endothelial Glycocalyx appeared first on The Nutrition Supplement Dietitian.

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This video from Dr. Derrick DeSilva, Jr, MD* explains how the endothelial glycocalyx functions as a protective barrier for arteries and other blood vessels, allowing the blood to flow without impacting the inner wall of the blood vessels.  Special nutrients (found in Arterosil HP) can help support and maintain a healthy glycocalyx, promoting overall cardiovascular well-being.

The endothelial glycocalyx has to be supported on an ongoing basis; many stressors such as smoking, high blood sugar, high blood pressure, air pollutants and even aging, pose a challenge to this lining.

The glycocalyx has a vital role in maintaining the health of your arteries and heart.

Main points:

  • The glycocalyx is a delicate structure that protects the artery wall
  • Behind the glycocalyx, the endothelium lines all arteries, veins, and capillaries
  • A healthy glycocalyx prevents blood particles from touching the endothelial layer
  • Special nutrients can help support a healthy glycocalyx
  • A healthy glycocalyx promotes healthy arteries and heart

*Dr DeSilva, a NJ-based medical doctor, is an advisor to Calroy Health Sciences, makers of Arterosil HP and Vascanox HP.

Watch the video below.


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Your Gut and Mental Health https://mysupplementrd.com/your-gut-and-mental-health/ Fri, 07 Jul 2023 16:49:46 +0000 https://mysupplementrd.com/?p=13059 The post Your Gut and Mental Health appeared first on The Nutrition Supplement Dietitian.

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The Gut-Brain Axis — The Powerful Connection Between Your Gut & Mental Health

Psychobiotic Revolution

Did you know that the microbes in your gut play a major role in your mood and cognitive function?

Microbes that have a positive impact on mood and mental health are called “psychobiotics.”


How does this happen?

Through various avenues, your gut microbiota can communicate with your brain. 

Microbes in the gut communicate bi-directionally with the brain and central nervous system through the Gut-Brain Axis.

Gut bacteria affect production of different neurotransmitters that affect mood! 

Did you know that the gut produces 90% of the body’s serotonin? 

And, if your microbiota get out of balance (dysbiosis), it can lead to chronic inflammation, a root cause of anxiety and depression.

Learn more about The Psychobiotic Revolution: Mood, Food and the New Science of the Gut-Brain Connection


Using Food, Nutrition and Psychobiotics to Support Your Mood

The food you eat directly affects the make-up of your gut microbiome. 

In turn, your gut microbiome affects your mood, overall mental health, and predisposition to anxiety and depression.

What’s the Best Diet for Mood?

The best diet for mood is a healthy whole foods diet.

This means lots of colorful fruits and vegetables, whole grains, nuts, seeds, healthy fats, and lean protein. 

These foods provide nourishment for gut bacterial strains that can have a positive effect on your mental health.

On the other hand, a highly processed, high sugar, low fiber diet with few fruits and vegetables, unhealthy fats, etc., promotes dysbiosis. 

Gut dysbiosis is associated with poor mood.


Bifidobacterium longum 1714  — Clinically Researched Psychobiotic

In addition to eating a healthy diet (which is foundational), one well-researched psychobiotic, Bifidobacterium longum 1714™ supports cognitive function, mood regulation, sleep quality, and the stress response.

There are some exciting new supplements with Bifidobacterium longum 1714™.

Zenbiome COPEZenbiome COPE

Bifidobacterium longum 1714™ psychobiotic enhanced with saffron and vitamins B6 and B12.

Supports production of brain chemicals that affect mood and brain function.


Zenbiome SLEEP

Zenbiome SLEEP

Bifidobacterium longum 1714™ psychobiotic enhanced with L-theanine, a relaxing amino acid that plays a role in formation of the stress modulating neurotransmitter GABA.

Also contains Lemon Balm, a calming herb that may help with insomnia.


Gut-Brain Reset Probiotic and Psychobiotic Combo

Gut-Brain Reset
Groundbreaking Psychobiotic/Probiotic for IBS and Associated Mood Issues

It’s common for people with IBS (irritable bowel syndrome) to also experience anxiety and depression.

Gut-Brain Reset is a unique supplement that addresses BOTH of these conditions — mood and IBS.

Gut-Brain Reset combines the psychobiotic Bifidobacterium longum 1714™ with Bifidobacterium longum 35624™, a probiotic studied for relief of IBS symptoms (constipation, diarrhea, gas, bloating, and abdominal discomfort).
IBS, anxiety and depression have all been linked to a dysfunctional microbiome, an altered immune response in the gut, and sensitivity to stress.


Researchers find that IBS, anxiety and depression share the same root cause of a dysregulated gut microbiome (dysbiosis).

The disruption of the gut-brain axis dysregulates the tryptophan/serotonin/melatonin pathway, shifting it toward producing neuroinflammatory by-products.

Gut-Brain Reset is a unique probiotic which combines Bifidobacterium longum 1714 (for low mood) and Bifidobacterium longum 35624 (for IBS).


 

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