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Nicotinamide-Riboside – Clinically Studied, Over 10 Years of Scientific Research
For Energy, Healthy Metabolism, and Neuroprotection
500 mg Niagen Per Capsule

Unique Molecule – Different than Niacin or Nicotinamide!
Nicotinamide Riboside is Found in Minute Amounts in Milk, Beer and Yeast

Nicotinamide Riboside is the Most Direct Precursor that Increases NAD⁺ Levels
Promotes Healthy Aging and Metabolism Through Sirtuin Activation

Nicotinamide Riboside was discovered in the 1940’s, but its activity as an NAD+ booster was discovered by Dr. Charles Brenner in 2004

Why is NAD+ So Important? 

This is how Niagen Bioscience explains it:

“NAD+ (nicotinamide adenine dinucleotide) is required by every living cell. It’s used to create the energy that powers your whole body, and is also essential in the processes of repair and recovery.

Your cells are really the building blocks of your life — not unlike the bricks that form the foundation of a house. When the foundation is sturdy, everything is sturdy. But you notice when things become unstable if the foundation starts to break down.

NAD+ declines as you get older (especially between age 30 and 70) and is also depleted by daily wear and tear on your body (from various factors that we refer to as “lifestyle stressors”).

It’s impossible to replenish your NAD+ supply via diet or exercise alone., which is why boosting NAD+ through supplementation is important if you want to maintain the cellular foundation of your health.”

150% increase in NAD+ in 3 weeks with 1000mg of Tru Niagen

Two randomized, double-blind, placebo-controlled studies with healthy subjects looked at the dose response of 1000mg of Tru Niagen supplementation on NAD+ levels.

Results show when Tru Niagen is supplemented orally, there was an average of a 150% increase in NAD+ in 3 weeks with 1000mg, compared to a 50% increase in NAD+ with 300mg. Read the study published in Nature here.

Nicotinamide Riboside → NAD^{+
(Nicotinamide Riboside is a direct precursor of NAD+)}

NAD+ is a catalyst that:

• Increases the body’s ability to produce energy (ATP) in the mitochondria and to make more mitochondria
• Supports cognitive function and provides neuroprotection
• Supports healthy metabolic function, including insulin sensitivity and support for fatty liver
• Promotes healthy aging by activating the sirtuin enzyme
  {SIRT1 and SIRT3 play key roles in healthy aging, fat metabolism, weight management, insulin resistance, nerve function, lipid metabolism in the liver.}
• Supports weight management by promoting thermogenesis
• Supports endurance athletes and fatigued individuals by increasing mitochondrial activity in the muscles, particularly cardiac muscle.

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For latest clinical research on NAD: www.aboutnad.com

The key ingredient in TRU NIAGEN® Pro is NIAGEN® nicotinamide riboside (NR)—a unique form of vitamin B3 clinically proven to increase nicotinamide adenine dinucleotide (NAD) [4-6], the critical catalyst that powers metabolism and helps maintain healthy cellular function.*

NAD has been shown to decline with age [7, 8] and metabolic stress [9-12]. It has also been demonstrated to help support many aspects of healthy aging.

Tru Niagen provides daily cellular care to help you age better® and live better, including:

• Replenishing NAD levels[4, 6, 13, 14]*
• Increasing cellular energy production[14]*
• Promoting healthy cellular metabolism[15-17]*
• Promoting cellular repair[7, 15, 17, 18]*
• Supporting healthy aging[4, 6, 13, 14]*

References

1. Rajman, L., K. Chwalek, and D.A. Sinclair, Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metab, 2018. 27(3): p. 529-547.
2. Verdin, E., NAD(+) in aging, metabolism, and neurodegeneration. Science, 2015. 350(6265): p. 1208-13.
3. Yoshino, J., J.A. Baur, and S.I. Imai, NAD(+) Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab, 2018. 27(3): p. 513-528.
4. Airhart, S.E., et al., An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS One, 2017. 12(12): p. e0186459.
5. Martens, C.R., et al., Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults. Nat Commun, 2018. 9(1): p. 1286.
6. Trammell, S.A., et al., Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun, 2016. 7: p. 12948.
7. Massudi, H., et al., Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One, 2012. 7(7): p. e42357.
8. Zhou, C.C., et al., Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. Br J Pharmacol, 2016. 173(15): p. 2352-68.
9. Canto, C., et al., The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab, 2012. 15(6): p. 838-47.
10. Gariani, K., et al., Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology, 2016. 63(4): p. 1190-204.
11. Seyssel, K., et al., Regulation of energy metabolism and mitochondrial function in skeletal muscle during lipid overfeeding in healthy men. J Clin Endocrinol Metab, 2014. 99(7): p. E1254-62.
12. Wang, S., et al., Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1alpha/mitochondrial biosynthesis pathway. Redox Biol, 2018. 17: p. 89-98.
13. Dollerup, O.L., et al., A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr, 2018.
14. Martens, C.R., Denman, B.A., Mazzo, M.r., Armstrong, M.L., Reisdorph, N., McQueen, M.B., Chonchol, M.B., Seals, D.R., Chronic nicotinamide riboside supplementation is well-tolerated and effectively elevates NAD+ in healthy middle-aged and older adults. 2018, University of Colorado Boulder.
15. Bieganowski, P. and C. Brenner, Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell, 2004. 117(4): p. 495-502.
16. Guest, J., et al., Changes in oxidative damage, inflammation and [NAD(H)] with age in cerebrospinal fluid. PLoS One, 2014. 9(1): p. e85335.
17. Ratajczak, J., et al., NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells. Nat Commun, 2016. 7: p. 13103.
18. Zhu, X.H., et al., In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc Natl Acad Sci U S A, 2015. 112(9): p. 2876-81

Tru Niagen Pro 1000 mg is manufactured by Niagen Bioscience, Inc (formerly ChromaDex),

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(CoEnzyme Q10 100 mg)

8x Higher Absorption than Traditional CoQ10

Uses GammaSorb Plant-Based Delivery System for Greater Bioavailability

CoQ10 (Ubiquinone) is important:

• Supports energy production within cells
• Replenishes CoQ10 depleted by cholesterol-lowering statin drugs
• Reduces the risk of oxidative stress
• Supports cellular energy for healthy aging
• Supports cognitive health, helps preserve neural connections, and healthy brain function

CoQ10 is Essential for Optimal Health

Every cell in our bodies has microscopic engines called mitochondria and the fuel for these engines is CoQ10.

CoQ10 sparks the process of moving electrons to create Adenosine Triphosphate (ATP), which powers your body at a microscopic level. Your heart, brain, and every energy-intensive aspect of your body and mind need a lot of CoQ10 to work optimally.

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