Histamine Digest PureMAX with DAOgest– For Those with Multiple Sensitivities and Higher DAO Needs

DAO – Diamine Oxidase Enzyme – Enzyme for Histamine Imbalance (Histamine Neutralizing Enzyme)

Purest Formulation of DAO from OmneDiem 

4.8 mg of natural diamine oxidase per capsule delivering 40,000 HDU

Supports Healthy Degradation of Food-Derived Histamine

Many foods contain histamine and/or cause the release of histamine in the gut. Diamine Oxidase (DAO) is the primary enzyme responsible for degrading dietary histamine in the GI tract.

Some people don’t produce a sufficient amount of Diamine Oxidase (DAO).

In that case, providing an outside source of DAO such as the nutrition supplement Histamine Digest PureMAX may provide relief of symptoms from excessive histamine levels.

Histamine Digest PureMAX contains a patented form of DAO that releases the enzyme in the small intestine where it acts directly on dietary histamine.

(According to the International Society of DAO Deficiency, the main cause of the enzymatic dysfunction is a person’s genetics.)

How is OmneDiem Histamine Relief PureMAX Different From Omne Diem Histamine Digest?

Histamine Relief PureMAX contains 40,000 HDU of diamine oxidase per capsule vs Histamine Digest which contains 20,000 HDU diamine oxidase per capsule.

Histamine Relief PureMAX does not contain Vitamin C (ascorbyl palmitate) or catalase, both of which are in the regular Histamine Digest DAO product. The omission of these extra ingredients makes Histamine Relief PureMAX the preferred form of DAO for sensitive individuals.

Both Histamine Relief PureMAX and Histamine Digest have designed release capsules that ensure delivery to the small intestine.

Per the manufacturer OmneDiem, regarding their 2024 reformulation of Histamine Digest PureMAX:

“Diamine oxidase, like other enzymes, is a delicate molecule that is most active when it is kept away from extreme environments, heat and humidity being two examples. By keeping diamine oxidase’s specific needs in mind, we’ve been able to customize the manufacturing process keeping it more stable and more active during extraction to yield an increased enzymatic activity and more HDU. It is thanks to these improvements in manufacturing that we can obtain a higher enzymatic activity out of the same amount of starting material.”

What are some symptoms of histamine intolerance?

The ingestion of histamine-rich food or of alcohol or drugs that release histamine or block DAO may provoke diarrhea, headache, rhinoconjunctival symptoms, asthma, hypotension, arrhythmia, urticaria, pruritus, flushing, and other conditions in patients with histamine intolerance.
— From the American Journal of Clinical Nutrition

DAO Enzyme is Clinically Tested to Break Down Dietary Histamines

The DAO enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract.

DAO is not absorbed and does not have systemic activity. Click to see the biochemistry of how DAO helps break down histamine.

Is Histamine Intolerance the Same as Mast Cell Activation Syndrome (MCAS)?

Histamine Intolerance and Mast Cell Activation Syndrome are different, but related.

In Mast Cell Activation Syndrome, a condition when body’s innate immune system is hyperactive, mast cells release many different chemical mediators, with histamine being just one of them.

More Information – Great Resources About Histamine Intolerance

Histamine Intolerance & Mast Cell Activation Flow Chart – triggers and symptoms – from www.histamine-intolerance.info

International Society of DAO Deficiency – everything from what DAO deficiency is, its origins, foods high in histamines, foods which interfere with histamine metabolism (including DAO-blocking foods), latest international research

Swiss Interest Group Histamine Intolerance (SIGHI) – information about histamine related disorders (histaminosis) — including cooking tutorials, recipes, and links to apps for histamine food values.

Note: Histamine Digest PureMAX does not manage or address antibody-related or IgE-related food allergies.

From OmneDiem®

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Soothing Power of Eucalyptus, Myrtle and Lemon Extract for Sinus and Immune Support

Supports Healthy Sinus Cilia Activity to Clear and Soothe Mucous Membranes without Drying Out

Sinutol Extra Strength provides the soothing power of eucalyptus, myrtle, and lemon extract to support sinus health and maintain clear bronchial passages, healthy mucous drainage.

The enteric-coated softgel allows for providing extra-strong sinus support while being gentle for those with gastrointestinal sensitivities (eliminates burping or aftertaste).

In addition, Sinutol Extra Strength helps provide support without drowsiness or jitters.

Three Powerful Botanicals for Sinus, Lung and Bronchial Support

The concentrated ingredients in Sinutol Extra Strength support the cilia of the sinuses, which brush mucus out of the sinus and nasal cavities. The result is effective respiratory support comfort without drowsiness or dry nasal passages.

• Refreshing Eucalyptus (Eucalyptus radiata) provides powerful compounds, including alpha pinene, and 1,8 cineole. It has long been studied and shown to support healthy, clear sinus passages.

• Strong Myrtle (Myrtus communis) supports a healthy respiratory environment and, like eucalyptus, also provides alpha pinene and 1,8 cineole.*

• Powerful Lemon (Citrus limon) provides additional sinus and immune support.

An enteric-coated soft gel is used because the concentrated eucalyptus oil is very powerful.

The enteric-coated softgel allows the ingredients to be released in the intestines, rather than the stomach, to prevent any gastric discomfort, aftertaste, or burps.

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Supports Seasonal Environmental Allergy Sufferers
Promotes Healthy Nasal and Sinus Passages for Individuals with Elevated Histamine and Respiratory Irritation

Supports Healthy Histamine Levels

Targeted Blend of Flavonoids, Antioxidants, Proteolytic Enzymes and Botanicals
Botanical + Nutrients, Non-Drowsy Formula

The Natural D-Hist formula includes optimal support for nasal and sinus passageways for individuals who anticipate seasonal changes.

Natural D-Hist is a targeted blend designed to provide comprehensive support for seasonal challenges caused by common environmental allergens. The formula includes quercetin, bromelain, stinging nettles leaf, N-acetyl cysteine and vitamin C. The powerful combination actively promotes healthy nasal and sinus passages for individuals with elevated histamine and respiratory irritation.

Natural D-Hist, Ingredient Benefits

Quercetin – Quercetin is a powerful flavonoid to support histamine levels. Naturally found in many plant foods, quercetin has strong antioxidant activity and has been shown to support immune health by mediating the release of inflammatory compounds including leukotrienes and prostaglandins. Quercetin is known for its ability to stabilize mast cells, diminishing the release of histamine, the compound known to cause hypersensitivity reactions during seasonal changes.

Quercetin is naturally found in many plant foods, such as apples, onions, teas, berries, cabbage family vegetables, dill, oregano, chili pepper, leafy green vegetables, broccoli, seeds, and nuts.

Stinging Nettles Leaf Extract – Stinging nettles leaf plant (Urtica dioica) has been shown to balance the hyper-immune response, specifically in the airways and nasal passages. Studies have shown that the extract of stinging nettles leaf balances a variety of inflammatory activities that affect respiratory health. Stinging nettles leaf controls mast-cell degranulation, prostaglandin formation, and histamine action all contributing to a balanced inflammatory response.

Bromelain – Bromelain enhances the absorption of quercetin and supports mucosal tissue health. Bromelain is a plant enzyme naturally found on the stem and fruit of the pineapple plant. Bromelain is a proteolytic (protein-digesting) enzyme that aids in in the breakdown of large protein complexes, including antigenic compounds and has been shown to enhance absorption of quercetin. Bromelain has also been shown to reduce circulating allergenic protein complexes associated with hyper-immune sensitivity and seasonal discomfort.

N-Acetyl Cysteine – N-acetyl cysteine (NAC) is an amino acid precursor to one of the most important antioxidants in the body, glutathione. Both glutathione and NAC help reduce the viscosity of the mucus allowing for clearing of the airways and improved respiratory health.

Vitamin C – Vitamin C cannot be synthesized by humans and is therefore an essential nutrient that must be consumed in the diet. Among its numerous health-promoting properties, vitamin C is an essential vitamin that supports the immune system and is also a potent antioxidant. When the body is under a significant amount of stress, vitamin C is excreted rapidly. Vitamin C has many immune boosting properties, but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine.Vitamin C works with quercetin to support glutathione, the body’s master antioxidant.

From Ortho Molecular Products

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Clinically Studied, Safe Butterbur

Butterbur Without PA’s (pyrrolizidine alkaloids)

Standardized Botanical Butterbur Formula, Evidence-Based Efficacy

Based on clinical trials, Petadolex, the PA-free form of Butterbur is considered the #1 migraine prophylactic compared to NSAIDS (non-steroidal inflammatory drugs, e.g. ibuprofen), and any other complementary therapies. —  American Academy of Neurology (AAN) and American Headache Society

The AAN evidence-based guideline states: there is strong evidence (Level A) that petasites (butterbur) is established as effective and should be offered for migraine prevention.

Petadolex is the only brand of butterbur root extract that has been used in clinical trials and the only butterbur root extract that uses a patented manufacturing process to remove PA’s that occur naturally in butterbur.

From the Report of the Quality Standards Subcommittee of the American Academy of Neurology, April 2012, referring to PA-free Butterbur:

“Effective for maintaining neurological health and should be offered to patients for healthier blood vessel flow in the brain.”

After 3 months on Petadolex (75 mg twice daily)– 71% of adults experienced a reduction in migraine attacks by 50% or more, as demonstrated in clinical studies published in peer-reviewed medical journals.

How Does Petadolex Work?

Petadolex works by helping to maintain smooth muscle tone in cerebral blood vessels, and through its anti-inflammatory and analgesic (pain-relieving) properties. On a chemical level, its active ingredients petasin and isopetasin, inhibit the synthesis of both inflammatory leukotrienes (LOX) and COX-2 enzymes.

However, Petadolex does not produce relief immediately; it has to build up in your body’s system (it may take up to 3 months) to experience maximum benefits.

Nonetheless, clinical trials have shown that even after 4 weeks on Petadolex (150 mg/day), 54% of adults experienced a 50% reduction in migraine attacks (frequency and migraine pain).

While the natural whole plant form of Butterbur contains pyrrolizidine alkaloids or PAs, these toxic compounds are all removed in the Petadolex manufacturing process.

Weber & Weber cultivates and processes their own butterbur plants using their patented process that extracts and purifies the active ingredient of butterbur — petasin. Petadolex is at least 15% petasin extract.

Used for over 30 years by neurologists in Europe.

How Do You Know if Petadolex is Appropriate for You?

If you are afflicted by headaches, it’s best to consult with your primary medical doctor, neurologist or headache specialist.

He or she will likely make an assessment as to what specific type of headaches (e.g. migraine, cluster, tension) you are getting. Often one of the first steps is to have you keep a diary documenting your episodes.

The diary is a great tool to get a baseline about your headaches, their severity, symptoms, frequency, duration, time of day, and track possible triggers (like specific foods, hours of sleep). Often there is a pattern and which will help you and your physician determine how to best help you feel better.

If one or more of these conditions describes your migraine attacks, you may benefit from PA-free butterbur:

• you experience 2-3 attacks per month
• your attacks last more than 48 hours
• your pain is unbearable
• you experience neurological symptoms such as visual disturbances

It may take several months to determine if Petadolex relieves your migraine pain and/or frequency.

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Supports Allergy Sufferers by Helping Stabilize Mast Cell Membranes That Store and Release Histamines

Natural Plant Phytonutrient and Antioxidant

Helps Maintain Balanced Histamine Levels, Support Histamine Intolerance

Quercetin’s best known mechanism of action involves its ability to stabilize mast cell membranes, which in turns can decrease the release of histamine. In this way it provides nutritional support for individuals who occasionally suffer from allergies.

Other benefits include its cardiovascular support and protection of the gastrointestinal tract.

A number of quercetin’s beneficial effects appear to be due to its antioxidant activity. Quercetin can scavenge free radicals and inhibit the oxidation of LDL cholesterol.

By itself, and when paired with vitamin C, quercetin can reduce the incidence of oxidative damage to skin and nerves caused by glutathione depletion.

Phytosome Technology for Enhanced Absorption of Quercetin

This exclusive Thorne formula features quercetin bound to sunflower-sourced phospholipids to enhance its absorption.

Widely found in the plant kingdom, quercetin is the most abundant of the flavonoid molecules. It is found in numerous foods, including apples, onions, teas, berries, vegetables of the cabbage family, dill, oregano, chili pepper, leafy green vegetables, brocolli, seeds, and nuts.

The advantage attributable to Thorne’s Quercetin Phytosome is its advanced phytosome technology. Phytosome complexes are created by a patented process that binds a botanical extract to phospholipids – phospholipids are key components of cell membranes. In the case of Quercetin Phytosome, the quercetin is combined with sunflower-sourced phospholipids to create a phytosome complex that can easily cross the gut barrier.

More Information – Great Resources About Histamine Intolerance

Histamine Intolerance & Mast Cell Activation Flow Chart – triggers and symptoms – from www.histamine-intolerance.info

International Society of DAO Deficiency – everything from what DAO deficiency is, its origins, foods high in histamines, foods which interfere with histamine metabolism (including DAO-blocking foods), latest international research

Swiss Interest Group Histamine Intolerance (SIGHI) – information about histamine related disorders (histaminosis) — including cooking tutorials, recipes, and links to apps for histamine food values.

Quercetin and Viruses

Quercetin has been shown to have antiviral effects against RNA (influenza and coronavirus) and DNA viruses (herpes virus).

Quercetin inhibits viral replication (promotes viral eradication or inactivation), modulates pro-inflammatory cytokines, and has healing anti-fibrotic properties through modulating mast cell stabilization.

From Thorne Research, Inc.

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DAO – Diamine Oxidase Enzyme – Enzyme for Histamine Imbalance

Omne Diem® Histamine Digest — The Histamine Neutralizing Enzyme with DAOgest
Supports Healthy Degradation of Food-Derived Histamine

Many foods contain histamine and/or cause the release of histamine in the gut. Diamine Oxidase (DAO) is the primary enzyme responsible for degrading dietary histamine in the GI tract.

Some people don’t produce a sufficient amount of Diamine Oxidase (DAO).

In that case, providing an outside source of DAO such as the nutrition supplement Histamine Digest (formerly labeled Umbrellux DAO2) may provide relief of symptoms from excessive histamine levels.

Histamine Digest contains a patented form of DAO that releases the enzyme in the small intestine where it acts directly on dietary histamine.

(According to the International Society of DAO Deficiency, the main cause of the enzymatic dysfunction is a person’s genetics.)

Histamine Digest is an advanced second-generation formulation of DAO (DAOgest)with catalase and ascorbyl palmitate  (vitamin C) to enhance activity. DAO is delivered with a patented Designed Release capsule that releases in the small intestine where DAO acts directly on the dietary histamine to support digestive health and comfort.

NOTE: Some very sensitive individuals prefer another DAO product from Omne DIEM – Histamine Digest PureMAX, as it does not contain catalase or vitamin C.

What are some symptoms of histamine intolerance?

The ingestion of histamine-rich food or of alcohol or drugs that release histamine or block DAO may provoke diarrhea, headache, rhinoconjunctival symptoms, asthma, hypotension, arrhythmia, urticaria, pruritus, flushing, and other conditions in patients with histamine intolerance.
— From the American Journal of Clinical Nutrition

DAO Enzyme is Clinically Tested to Break Down Dietary Histamines

The DAO enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract.

DAO is not absorbed and does not have systemic activity. Click to see the biochemistry of how DAO helps break down histamine.

Is Histamine Intolerance the Same as Mast Cell Activation Syndrome (MCAS)?

Histamine Intolerance and Mast Cell Activation Syndrome are different, but related.

In Mast Cell Activation Syndrome, a condition when body’s innate immune system is hyperactive, mast cells release many different chemical mediators, with histamine being just one of them.

More Information – Great Resources About Histamine Intolerance

Histamine Intolerance & Mast Cell Activation Flow Chart – triggers and symptoms – from www.histamine-intolerance.info

International Society of DAO Deficiency – everything from what DAO deficiency is, its origins, foods high in histamines, foods which interfere with histamine metabolism (including DAO-blocking foods), latest international research

Swiss Interest Group Histamine Intolerance (SIGHI) – information about histamine related disorders (histaminosis) — including cooking tutorials, recipes, and links to apps for histamine food values.

Note: Histamine Digest does not manage or address antibody-related or IgE-related food allergies.

From Omne Diem®.

The post Histamine Digest with DAOgest™ – formerly Umbrellux DAO2 appeared first on The Nutrition Supplement Dietitian.