Readily Absorbed Form of Vitamin K2 — Made From Fermented Chickpeas

Regulates Calcium Balance, Directing Calcium to Bones, Not Blood Vessels

• Stays in Body Longer: The MK-7 form of Vitamin K2 has a longer half life compared to the MK-4 form of menaquinones. This means that MK-7 stays active in your body for a more extended period.
• Sourced from Nature: Made from fermented chickpeas, distinguishing it from synthetic forms of Vitamin K2 (MK-4) and other natural forms of MK-7 which are frequently soy-based.
• Enhanced Bioavailability with MenaQ7®: This supplement features MenaQ7®, a clinically studied form of Vitamin K2. MenaQ7® is easily absorbed and utilized by your body.

How to Optimize Absorption of Vitamin K2

The post Protocol for Life Balance MK-7 — 160 mcg Vitamin K2 appeared first on The Nutrition Supplement Dietitian.

Nicotinamide-Riboside – Clinically Studied, Over 10 Years of Scientific Research
For Energy, Healthy Metabolism, and Neuroprotection
500 mg Niagen Per Capsule

Unique Molecule – Different than Niacin or Nicotinamide!
Nicotinamide Riboside is Found in Minute Amounts in Milk, Beer and Yeast

Nicotinamide Riboside is the Most Direct Precursor that Increases NAD⁺ Levels
Promotes Healthy Aging and Metabolism Through Sirtuin Activation

Nicotinamide Riboside was discovered in the 1940’s, but its activity as an NAD+ booster was discovered by Dr. Charles Brenner in 2004

Why is NAD+ So Important? 

This is how Niagen Bioscience explains it:

“NAD+ (nicotinamide adenine dinucleotide) is required by every living cell. It’s used to create the energy that powers your whole body, and is also essential in the processes of repair and recovery.

Your cells are really the building blocks of your life — not unlike the bricks that form the foundation of a house. When the foundation is sturdy, everything is sturdy. But you notice when things become unstable if the foundation starts to break down.

NAD+ declines as you get older (especially between age 30 and 70) and is also depleted by daily wear and tear on your body (from various factors that we refer to as “lifestyle stressors”).

It’s impossible to replenish your NAD+ supply via diet or exercise alone., which is why boosting NAD+ through supplementation is important if you want to maintain the cellular foundation of your health.”

150% increase in NAD+ in 3 weeks with 1000mg of Tru Niagen

Two randomized, double-blind, placebo-controlled studies with healthy subjects looked at the dose response of 1000mg of Tru Niagen supplementation on NAD+ levels.

Results show when Tru Niagen is supplemented orally, there was an average of a 150% increase in NAD+ in 3 weeks with 1000mg, compared to a 50% increase in NAD+ with 300mg. Read the study published in Nature here.

Nicotinamide Riboside → NAD^{+
(Nicotinamide Riboside is a direct precursor of NAD+)}

NAD+ is a catalyst that:

• Increases the body’s ability to produce energy (ATP) in the mitochondria and to make more mitochondria
• Supports cognitive function and provides neuroprotection
• Supports healthy metabolic function, including insulin sensitivity and support for fatty liver
• Promotes healthy aging by activating the sirtuin enzyme
  {SIRT1 and SIRT3 play key roles in healthy aging, fat metabolism, weight management, insulin resistance, nerve function, lipid metabolism in the liver.}
• Supports weight management by promoting thermogenesis
• Supports endurance athletes and fatigued individuals by increasing mitochondrial activity in the muscles, particularly cardiac muscle.

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For latest clinical research on NAD: www.aboutnad.com

The key ingredient in TRU NIAGEN® Pro is NIAGEN® nicotinamide riboside (NR)—a unique form of vitamin B3 clinically proven to increase nicotinamide adenine dinucleotide (NAD) [4-6], the critical catalyst that powers metabolism and helps maintain healthy cellular function.*

NAD has been shown to decline with age [7, 8] and metabolic stress [9-12]. It has also been demonstrated to help support many aspects of healthy aging.

Tru Niagen provides daily cellular care to help you age better® and live better, including:

• Replenishing NAD levels[4, 6, 13, 14]*
• Increasing cellular energy production[14]*
• Promoting healthy cellular metabolism[15-17]*
• Promoting cellular repair[7, 15, 17, 18]*
• Supporting healthy aging[4, 6, 13, 14]*

References

1. Rajman, L., K. Chwalek, and D.A. Sinclair, Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metab, 2018. 27(3): p. 529-547.
2. Verdin, E., NAD(+) in aging, metabolism, and neurodegeneration. Science, 2015. 350(6265): p. 1208-13.
3. Yoshino, J., J.A. Baur, and S.I. Imai, NAD(+) Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab, 2018. 27(3): p. 513-528.
4. Airhart, S.E., et al., An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS One, 2017. 12(12): p. e0186459.
5. Martens, C.R., et al., Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults. Nat Commun, 2018. 9(1): p. 1286.
6. Trammell, S.A., et al., Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun, 2016. 7: p. 12948.
7. Massudi, H., et al., Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One, 2012. 7(7): p. e42357.
8. Zhou, C.C., et al., Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. Br J Pharmacol, 2016. 173(15): p. 2352-68.
9. Canto, C., et al., The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab, 2012. 15(6): p. 838-47.
10. Gariani, K., et al., Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology, 2016. 63(4): p. 1190-204.
11. Seyssel, K., et al., Regulation of energy metabolism and mitochondrial function in skeletal muscle during lipid overfeeding in healthy men. J Clin Endocrinol Metab, 2014. 99(7): p. E1254-62.
12. Wang, S., et al., Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1alpha/mitochondrial biosynthesis pathway. Redox Biol, 2018. 17: p. 89-98.
13. Dollerup, O.L., et al., A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr, 2018.
14. Martens, C.R., Denman, B.A., Mazzo, M.r., Armstrong, M.L., Reisdorph, N., McQueen, M.B., Chonchol, M.B., Seals, D.R., Chronic nicotinamide riboside supplementation is well-tolerated and effectively elevates NAD+ in healthy middle-aged and older adults. 2018, University of Colorado Boulder.
15. Bieganowski, P. and C. Brenner, Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell, 2004. 117(4): p. 495-502.
16. Guest, J., et al., Changes in oxidative damage, inflammation and [NAD(H)] with age in cerebrospinal fluid. PLoS One, 2014. 9(1): p. e85335.
17. Ratajczak, J., et al., NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells. Nat Commun, 2016. 7: p. 13103.
18. Zhu, X.H., et al., In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc Natl Acad Sci U S A, 2015. 112(9): p. 2876-81

Tru Niagen Pro 1000 mg is manufactured by Niagen Bioscience, Inc (formerly ChromaDex),

The post Tru Niagen Pro 1000 mg – Nicotinamide Riboside appeared first on The Nutrition Supplement Dietitian.

Highly Absorbable, Bioavailable
Preferred Form – Ubiquinol vs. Ubiquinone
100% Natural CoQ10

Arterial and Cardiovascular Support
Antioxidant /Active Scavenger of Free Radicals

Not all CoQ10 Supplements are Equal, Ubiquinol is More Available, Natural

I believe this CoQ10 Ubiquinol supplement is superior and worth the extra cost than what you’ll find at “big box” stores because:

• It is the Ubiquinol form of CoQ10 (also known as the reduced form). It is NOT the Ubiquinone (or oxidized) form of the coenzyme.
  • CoQ10 Ubiquinol is about twice as absorbable as the Ubiquinone form of CoQ10.
  • Ubiquinol is the primary form of CoQ10 found in the blood.
  • Ubiquinol is the active antioxidant form.
  • Your body may not be able to utilize the cheaper Ubiquinone form of CoQ10. In order to be able to use Ubiquinone, your body has to first convert it to Ubiquinol. The ability of the body to make this conversion naturally decreases with age.
• This Ubiquinol is Natural Ubiquinol vs. Others That are Synthetic Ubiquinol.
  • Protocol for Life uses KanekaQH Ubiquinol. It is naturally produced by microbial fermentation resulting in a naturally structured product (trans-isomer) that is utilized by the body.
  • In contrast, synthetic forms of Ubiquinol (and Ubiquinone, for that matter), are produced from a compound extracted from tobacco leaf. In this processing, cis as well as trans-isomers are produced.
  • The cis-isomers found in synthetically made Ubiquinol do not occur naturally in the body.

What Does CoQ10 Ubiquinol Do?

CoQ10, in the form of ubiquinol, is found inside the mitochondria (or “battery”) of every cell. Organs with higher energy requirements (kidneys, liver, heart) have particularly high concentrations of ubiquinol.

CoQ10 is a powerful fat-soluble free radical scavenger that helps protect cell membranes against free radical attack and oxidative stress. Oxidative stress can damage phospholipids in cell and mitochondrial membranes and can alter DNA, including in vascular structures, blood, brain and neurons. Without protection of this natural antioxidant, low density lipoproteins (LDLs) in the blood may become more damaging to the blood vessels.

CoQ10 is:

• essential for use in cellular energy production and cardiovascular support.
• synthesized by the body
• found in foods like oily fish (e.g., salmon and tuna), organ meats (e.g. liver), soy and sesame oils, and whole grains.

CoQ10 and Good Health

Many medical studies demonstrate beneficial effects of CoQ10 in heart-related conditions. They attribute this to its vital role in oxygen utilization and improving energy production, particularly in heart muscle cells.

CoQ 10 is beneficial for cardiovascular health in many ways. For example, CoQ10 assists in maintaining the normal oxidative state of LDL cholesterol, helps assure circulatory health, and supports optimal functioning of the heart muscle. CoQ10 also “relaxes” blood vessels and may play a beneficial role in the treatment of high blood pressure.

The reality is, as we age, even in middle age, there is a natural decline in the body’s production of CoQ10 Ubiquinol as well as a decrease in the efficiency of utilizing it.

History of CoQ10 as a Nutritional Supplement

Identified in 1957 and in 1974, Coenzyme Q10 (ubiquinone/ubiquinol) was approved by the Japanese government for congestive heart failure treatments. Today it is used by millions of people in Japan, especially as part of a medical protocol for cardiovascular disease. CoQ10 is also an extensively used supplement in Europe and Russia.

What About CoQ10 and Statins?

Those who are taking statins (HMG coenzyme A reductase inhibitors) to lower cholesterol may be at particular risk for deficiency because not only do statins reduce cholesterol levels but they also block CoQ10 synthesis in the body. (Statins interfere with the production of a precursor in the synthesis of CoQ10 called mevalonic acid.)

The statin medications routinely result in lower CoQ10 levels in the serum and muscle tissue. Some, not all medical practitioners, believe that low CoQ10 levels in patients on statins may contribute to the common side effects of statin therapy such as fatigue and aching muscles.

If you are on a statin, you should consult with your own medical doctor as to his or her own recommendation regarding taking a CoQ10 nutritional supplement.

The post CoQ10 Ubiquinol 100 mg – Cardiovascular, Cellular Support appeared first on The Nutrition Supplement Dietitian.

Comprehensive B Vitamin Complex Support – Highly Bioavailable Forms
Hypoallergenic, Foundational Nutrition

Roles of the B Vitamin Family

The post Active B-Complex Vitamins appeared first on The Nutrition Supplement Dietitian.