Consultation with Registered Dietitian Nutritionist, Janet Zarowitz, MS, RD, CDN
Using Genetic Clues to Optimize and Personalize Nutrition

Nutrigenomics uses genetic clues to customize and optimize your nutrition.

Your consultation will include a review of your SNPs, discussion of signs of their expression, and a nutrition protocol to optimize the potential weaknesses of your SNPs.

The PureGenomics Report covers genes and nutritional supports related to: 

• vitamins, minerals
• detoxification pathways
• weight management and metabolism
• cardiovascular health
• GI health
• cognitive health and memory
• immune health
• energy and fitness
• glucose metabolism
• antioxidant and cellular defense
• methylation pathways
• new nutrigenomics reports are being added

Your PureGenomics consultation can be in-person in the Westchester, NY office or remotely via telehealth (phone or video chat).

What’s the Methylation Pathway?

Why is Methylation so Important?

• homocysteine clearance
• neurotransmitter production
• hormone detoxification
• amino acid production
• utilization and assimilation of vitamins
• DNA synthesis
• gene regulation.

How the PureGenomics Nutrigenomics Consultation Works

The post PureGenomics Nutrigenomics Consultation appeared first on The Nutrition Supplement Dietitian.

Targeted Support for MTHFR SNPs in the Methylation Pathway
Based on Nutrigenomics

Naturally occurring, universally metabolized form of folate (Metafolin® brand)

Metafolin® is chemically identical to the active folate metabolite, 5-methyl-tetrahydrofolate (L-5-MTHF). This is the predominant, naturally occurring form of folate in food.

This form of folate is directly usable by the body because it bypasses several enzymatic activation steps. Metafolin provides all of the benefits of folic acid regardless of functional or genetic variations.

The L-5-MTHF active form of folate is important for individuals with a MTHFR variation — A1298C and/or C677T. People with MTHFR SNPs may have a reduced ability to activate folic acid to the form that the body can utilize.

Genetic variations affecting activation and metabolism of supplemental folic acid are highly prevalent.

Manufactured and formulated by Pure Encapsulations, Sudbury, MA.

The post Folate 1000 Metafolin appeared first on The Nutrition Supplement Dietitian.

Supports the Methylation Pathway

This supplement provides 50 mg. of activated B6 (pyridoxal-5-phosphate), the predominant form of circulating B6.

People with genetic variations in the CBS gene may have an up-regulation in this gene. Thus they may have an increased requirement for P-5-P.

Why P-5-P, the Activated Vitamin B6 Preferred?

P-5-P is the special form of Vitamin B6 that your body can easily utilize. It’s the activated form of B6. In fact, the other forms of B6 have to first be converted into P-5-P in order for their bodies to be able to use it.

The forms of Vitamin B6 that have to be converted into P-5-P in order to be utilized as a coenzyme are: pyridoxine, pyridoxal, or pyridoxamine.

Conversion of non-P-5-P forms of Vitamin B6 to P-5-P occurs in the intestinal absorptive cells or the liver.

But what if this conversion is not optimal? This can be the case in older adults, people with impaired liver function or those with GI issues, (e.g. celiac disease or GI inflammation).

Vitamin B6 in its active form (P-5-P) is the form that the body can most readily utilize.

Physiological Roles of Vitamin B6

Vitamin B6 plays many key roles in the body. For example Vitamin B6 is needed for:

• amino acid metabolism and neurotransmitter production and detoxification
• proper absorption of vitamin B12 and magnesium
• production of gastric acid needed for digestion and gut microbial health
• production of antibodies and red blood cells
• energy production in the liver and muscles
• metabolism of carbohydrates and fats
• maintaining sodium and potassium balance (Na:K balance regulates body fluids and promotes the healthy functioning of the nervous and musculoskeletal systems.)
• reducing pain and inflammation in early stages of carpal tunnel syndrome

The post P-5-P Activated Vitamin B6 appeared first on The Nutrition Supplement Dietitian.