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Nicotinamide Riboside – 500 mg – Tru Niagen Pro 500 by ChromaDex

Nicotinamide Riboside – 500 mg – Tru Niagen Pro 500 by ChromaDex

$73.30

500 mg Nicotinamide Riboside (Niagen) – per capsule
Unique Patented Ingredient
Different from Niacin or Nicotinamide and No Flushing

Clinically Studied Nutritional Precursor that Increases NAD+ Levels – for Energy, Metabolism and Cognitive Support

NAD+ supports mitochondrial efficiency/mitochondrial biogenesis
NAD+ regulates sirtuin activity – supports fat metabolism, weight management, insulin resistance, nerve function and healthy aging

From ChromaDex

30 capsules

Formulated without nuts or gluten
Does not contain animal byproducts, no artificial colors or flavors

 

Product Description

500 mg dose

Nicotinamide-Riboside – Clinically Studied, Over 10 Years of Scientific Research
For Energy, Healthy Metabolism, and Neuroprotection

Unique Molecule – Different than Niacin or Nicotinamide!
Nicotinamide Riboside is Found in Minute Amounts in Milk, Beer and Yeast

Nicotinamide Riboside is the Most Direct Precursor that Increases NAD+ Levels
Promotes Healthy Aging and Metabolism Through Sirtuin Activation

Nicotinamide Riboside → NAD+
(Nicotinamide Riboside is a direct precursor of NAD+)

NAD+ is a catalyst that:

  • Increases the body’s ability to produce energy (ATP) in the mitochondria and to make more mitochondria
  • Supports cognitive function and provides neuroprotection
  • Supports healthy metabolic function, including insulin sensitivity and support for fatty liver
  • Promotes healthy aging by activating the sirtuin enzyme
    {SIRT1 and SIRT3 play key roles in healthy aging, fat metabolism, weight management, insulin resistance, nerve function, lipid metabolism in the liver.}
  • Supports weight management by promoting thermogenesis
  • Supports endurance athletes and fatigued individuals by increasing mitochondrial activity in the muscles, particularly cardiac muscle.

For latest clinical research on NAD: www.aboutnad.com

 


For more information with scientific references about Nicotinamide Riboside:


The key ingredient in TRU NIAGEN® Pro is NIAGEN® nicotinamide riboside (NR)—a unique form of vitamin B3 clinically proven to increase nicotinamide adenine dinucleotide (NAD) [4-6], the critical catalyst that powers metabolism and helps maintain healthy cellular function.*

NAD has been shown to decline with age [7, 8] and metabolic stress [9-12]. It has also been demonstrated to help support many aspects of healthy aging.

Tru Niagen provides daily cellular care to help you age better® and live better, including:

  • Replenishing NAD levels[4, 6, 13, 14]*
  • Increasing cellular energy production[14]*
  • Promoting healthy cellular metabolism[15-17]*
  • Promoting cellular repair[7, 15, 17, 18]*
  • Supporting healthy aging[4, 6, 13, 14]*

References

  1. Rajman, L., K. Chwalek, and D.A. Sinclair, Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metab, 2018. 27(3): p. 529-547.
  2. Verdin, E., NAD(+) in aging, metabolism, and neurodegeneration. Science, 2015. 350(6265): p. 1208-13.
  3. Yoshino, J., J.A. Baur, and S.I. Imai, NAD(+) Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab, 2018. 27(3): p. 513-528.
  4. Airhart, S.E., et al., An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS One, 2017. 12(12): p. e0186459.
  5. Martens, C.R., et al., Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults. Nat Commun, 2018. 9(1): p. 1286.
  6. Trammell, S.A., et al., Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun, 2016. 7: p. 12948.
  7. Massudi, H., et al., Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One, 2012. 7(7): p. e42357.
  8. Zhou, C.C., et al., Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. Br J Pharmacol, 2016. 173(15): p. 2352-68.
  9. Canto, C., et al., The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab, 2012. 15(6): p. 838-47.
  10. Gariani, K., et al., Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology, 2016. 63(4): p. 1190-204.
  11. Seyssel, K., et al., Regulation of energy metabolism and mitochondrial function in skeletal muscle during lipid overfeeding in healthy men. J Clin Endocrinol Metab, 2014. 99(7): p. E1254-62.
  12. Wang, S., et al., Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1alpha/mitochondrial biosynthesis pathway. Redox Biol, 2018. 17: p. 89-98.
  13. Dollerup, O.L., et al., A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr, 2018.
  14. Martens, C.R., Denman, B.A., Mazzo, M.r., Armstrong, M.L., Reisdorph, N., McQueen, M.B., Chonchol, M.B., Seals, D.R., Chronic nicotinamide riboside supplementation is well-tolerated and effectively elevates NAD+ in healthy middle-aged and older adults. 2018, University of Colorado Boulder.
  15. Bieganowski, P. and C. Brenner, Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell, 2004. 117(4): p. 495-502.
  16. Guest, J., et al., Changes in oxidative damage, inflammation and [NAD(H)] with age in cerebrospinal fluid. PLoS One, 2014. 9(1): p. e85335.
  17. Ratajczak, J., et al., NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells. Nat Commun, 2016. 7: p. 13103.
  18. Zhu, X.H., et al., In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc Natl Acad Sci U S A, 2015. 112(9): p. 2876-81

Tru Niagen Pro is manufactured by ChromaDex, It contains ChromaDex Inc.’s proprietary Nicotinamide Riboside.

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Ingredients

Each capsule contains 500 mg. of Nicotinamide Riboside.

This product contains ChromaDex Inc’s proprietary Nicotinamide Riboside ingredient Niagen®.

Niagen is a registered trademark of ChromaDex, Inc.

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Suggested Use

Take 1 capsule daily, with or without food, or as recommended by your health care practitioner.

If pregnant, nursing or taking any medications, consult your health-care practitioner before using the product.

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