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Petadolex – Butterbur for Migraine Prevention

Petadolex – Butterbur for Migraine Prevention


PA-free Butterbur, 75 mg.
Clinically Shown to Prevent Migraines
Used for Over 30 Years by Neurologists in Europe
Recommended by American Academy of Neurology

From Weber & Weber; Distributed by LinPharma

Safe, Free of Pyrrolizidine Alkaloids

No trans fat, peanuts, eggs, milk, wheat, gluten, tree nuts, fish or shellfish

60 gelcaps, each 75 mg.

Product Description

Petadolex, Clinically Studied, Safe Butterbur

Without PA’s (pyrrolizidine alkaloids)

Standardized Botanical Butterbur Formula, Evidence-Based Efficacy

Based on clinical trials, Petadolex, the PA-free form of Butterbur is considered the #1 migraine prophylactic compared to NSAIDS (non-steroidal inflammatory drugs, e.g. ibuprofen), and any other complementary therapies. —  American Academy of Neurology (AAN) and American Headache Society

The AAN evidence-based guideline states that there is strong evidence (Level A) that petasites (butterbur) is established as effective and should be offered for migraine prevention.

Petadolex is the only brand of butterbur root extract that has been used in clinical trials and the only butterbur root extract that uses a patented manufacturing process to remove PA’s that occur naturally in butterbur.

From the Report of the Quality Standards Subcommittee of the American Academy of Neurology, April 2012, referring to PA-free Butterbur:

“Effective for maintaining neurological health and should be offered to patients for healthier blood vessel flow in the brain.”

After 3 months on Petadolex*– 71% of adults experienced a reduction in migraine attacks by 50% or more, as demonstrated in clinical studies published in peer-reviewed medical journals. (*75 mg. Petadolex, twice daily; Petadolex also comes in a 50 mg. capsule, but it’s much more difficult to remember to take a supplement 3x vs. 2x/day!)

How Does Petadolex Work?

Petadolex works by helping to maintain smooth muscle tone in cerebral blood vessels, and through its anti-inflammatory and analgesic properties. On a chemical level, its active ingredients petasin and isopetasin, inhibit the synthesis of both inflammatory leukotrienes (LOX) and COX-2 enzymes.

However, Petadolex does not produce relief immediately; it has to build up in your body’s system (it may take up to 3 months) to experience maximum benefits.

Nonetheless, clinical trials have shown that even after 4 weeks on Petadolex (150 mg/day), 54% of adults experienced a 50% reduction in migraine attacks (frequency and migraine pain).

How Do You Know if Petadolex is Appropriate for You?

If you are afflicted by headaches, it’s best to consult with your primary medical doctor, neurologist or headache specialist.

He or she will likely make an assessment as to what specific type of headaches (e.g. migraine, cluster, tension) you are getting. Often one of the first steps is to have you keep a diary documenting your episodes.

The diary is a great tool to get a baseline about your headaches, their severity, symptoms, frequency, duration, time of day, and track possible triggers (like specific foods, hours of sleep). Often there is a pattern and which will help you and your physician determine how to best help you feel better.

If one or more of these conditions describes your migraine attacks, you may benefit from PA-free butterbur:

  • you experience 2-3 attacks per month
  • your attacks last more than 48 hours
  • your pain is unbearable
  • you experience neurological symptoms such as visual disturbances

It May Take Several Months to Determine if Petadolex Relieves Your Migraine Pain and/or Frequency

Most people with migraines do benefit from PA-free butterbur. However, about 3 of every 10 people will not experience benefit from this botanical supplement.

Some people will notice some migraine relief after one month or even one week on Petadolex, but for others it may take up to three months. It can take time for the butterbur to build up in your system.

Giving PA-free butterbur a full and fair trial, requires your commitment — you will need to use it every day, twice a day for 3 months.

However, both the impressive results and safety of this unique PA-free butterbur, make a very strong case for a seeing if it works for you in improving your quality of life.

Butterbur Has Been Used as Medicine in Historybutterbur petasites plant

Butterbur was used in the Middle Ages to treat the plague and is mentioned earlier by the ancient Greeks.Modern scientists have identified that butterbur has properties that are:

  • spasmolytic (muscle relaxing)
  • anti-inflammatory and
  • pain-relieving.

Butterbur is in daisy family – Asteracea. Other names for Butterbur include: Blatterdock, Bog Rhubarb, Bogshorns,  Capdockin, Flapperdock, Grand Bonnet, Japonica Petasites, Langwort, Petasites hybridus, and Purple Butterbur.


Petadolex is a Safe, Modern Form of Butterbur

While the natural whole plant form of Butterbur contains pyrrolizidine alkaloids or PAs, these toxic compounds are all removed in the Petadolex manufacturing process.

Weber & Weber cultivates and processes their own butterbur plants using their patented process that extracts and purifies the active ingredient of butterbur — petasin. Petadolex is at least 15% petasin extract.


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One gelcap contains:

Purple butterbur (Petasites hybridus) (root) Extract (28-44:1) Standardized for 11.25 mg. of Petasin and Isopetasin.

Petadolex is at least 15% petasin extract.

Butterbur (biological name, Petasites hybridus)

PA free – no detectable PA levels

Other Ingredients: Olive oil, glycerol, gelatin, medium chain triglycerides, sorbitol, mixed carotenoids (natural coloring).

Contains No: trans fat, peanuts, eggs, milk, wheat, gluten, tree nuts, fish or shellfish

Weber & Weber International, manufacturer of Petadolex gelcaps (in Germany), holds the world-wide patent to extract the medicinal petasites from the butterbur plant. Petasites do not contain the harmful liver toxins (pyrrolizidine alkaloids, or PAs) that occur naturally in the root of the butterbur plant.

In North America, Petadolex is distributed by Linpharma, Inc.

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Suggested Use

Adults, take one 75 mg. gelcap, two times a day (one in the morning and one in the evening), preferably with food, or as directed by your health care professional.

Petadolex should be not be taken during pregnancy, if you are planning on becoming pregnant or while breastfeeding, as there have not been specific studies conducted on this. It is also contra-indicated in patients with a prior history of any liver disease.

There are no known interactions between Petadolex and other medications.

PA-free butterbur is generally well tolerated. Side effects of are uncommon, however some people have experienced minor gastric complaints, such as burping or upset stomach and itchy eyes or fatigue. People who are allergic to plants in the same family as butterbur (e.g., ragweed, marigolds, daisies), may also have an allergic reaction to butterbur.

Although extremely rare, if you get symptoms of upper right abdominal pain, nausea, vomiting, or jaundice, stop taking Petadolex and consult your physician.

Keep Petadolex tightly closed and stored in a cool dry place.

Petadolex for Children

Petadolex has been shown to be extremely effective in children and adolescents (6-17 years), however a lower dosage is recommended (one 50 mg gelcap twice daily). You can contact me –  – about Petadolex50 gelcaps.

My Personal Experience

I used to get migraines often, so I know how it can affect someone’s quality of life and ability to just function.

I have heard very enthusiastic comments about the difference that Petadolex has made in people’s lives.

Some of my clients have also gotten improvement in the frequency of their migraines by eating a gluten-free and diary-free diet, and by making a conscious effort to get more hours of sleep and staying on a regular sleep schedule.


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