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Serum DAO May Help Diagnose Histamine Intolerance

Serum DAO May Help Diagnose Histamine Intolerance

Histamine intolerance may develop when the body doesn’t have the capacity to fully metabolize and degrade histamine.

Whether it’s from the histamines found in or triggered by food or medications, or from other environmental factors, this imbalance overwhelms the body.

The main enzyme that metabolizes ingested histamine is produced by the body, though often not in adequate amounts, is diamine oxidase. It is referred to as DAO.

In a 3 1/2 year study*, researchers determined that DAO (diamine oxidase) activity in serum along with a detailed history might be useful for a differential diagnosis between histamine intolerance and food allergy).

Their results also showed the benefit of histamine-free diet. After implementing the diet, a majority of histamine related symptoms disappeared and DAO activity in serum increased.


I have many clients who use Umbrellux-DAO enzyme supplement in addition to a reduced histamine diet, to manage their histamine intolerance and symptoms, particularly GI distress.

*Serum diamine oxidase (DAO) activity as a diagnostic test for histamine intolerance, Clinical Translational Allergy. 2011; 1(Suppl 1): P115.
Authors: Ema Music,  Mira Silar, Peter Korosec, Mitja Kosnik,and Matija Rijavec

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