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Study: Lower Serum DAO in Patients with Histamine Intolerance, Benefit with DAO Supplement

Study: Lower Serum DAO in Patients with Histamine Intolerance, Benefit with DAO Supplement

DAO (Diamine Oxidase) is the enzyme that breaks down histamine in the gut.

So what happens when you don’t have enough active DAO, or too high level of histamines?

Often this leads to Histamine Intolerance, also referred to as HIT. A common symptom is gastric hypersecretion manifested with GI discomfort when eating.

Many of my clients with histamine intolerance report relief when taking a DAO enzyme supplement just before eating meals.

This study concluded similarly, that people who exhibited a histamine intolerance, the majority of whom had lower serum DAO levels, benefited from DAO supplementation.

Excerpts From:
Serum diamine oxidase activity in patients with histamine intolerance

Intolerance to various foods, excluding bona fide coeliac disease and lactose intolerance, represents a growing cause of patient visits to allergy clinics. Histamine intolerance is a long-known, multifaceted clinical condition triggered by histamine-rich foods and alcohol and/or by drugs that liberate histamine or block diamine oxidase (DAO), the main enzyme involved in the metabolism of ingested histamine. Histamine limitation diets impose complex, non-standardized restrictions that may severely impact the quality of life of patients.

We found that 10 out of 14 patients had serum DAO activity<10 U/mL, which was the threshold suggested as a cutoff for probable histamine intolerance.

Moreover, 13 out of 14 patients subjectively reported a benefit in at least one of the disturbances related to food intolerances following diamine oxidase supplementation.

2016 Mar;29(1):105-11. doi: 10.1177/0394632015617170. Epub 2015 Nov 16.
Manzotti G, Breda D, Di Gioacchino M, Burastero SE

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