Arterosil HP®- Cardiovascular Health, Artery Support

$99.00

Supports the structure and normal functions of endothelial glycocalyx — the fragile inner lining of your vascular system*

Supports healthy blood pressure levels already in the normal range

Contains MonitumRS — a proprietary extract of rhamnan sulfate from the rare green seaweed Monostroma nitidum

Incorporates fruit and vegetable blend with antioxidant properties

Helps support normal artery function*

Supports normal circulation*

Helps maintain healthy artery wall*

Supports healthy heart*

Professional Grade, From Calroy Health Sciences

60 vegan capsules

Does not contain: dairy, gluten, soy

Non-GMO

Free Shipping in US

 

Product Description

Arterosil HP® – Vascular and Artery Support
Endothelial Glycocalyx Support

Supports Structure and Normal Functions of Endothelial Glycocalyx

Every blood vessel in your body is lined with a protective, yet fragile micro-thin gel called the endothelial glycocalyx which protects and regulates the entire vascular system and healthy circulation/blood flow.

A healthy glycocalyx is essential for healthy artery walls that can be impacted by aging, genetics and lifestyle choices.

Primary lifestyle contributors to the breakdown of the endothelial glycocalyx are high blood glucose, oxidative stress (eg. poor diet, environmental toxins, smoking) and inflammation.


How Does Arterosil HP Support the Endothelial Glycocalyx and Arterial Health? 

Arterosil HP provides sulfated polysaccharide building blocks and antioxidants that support the maintenance of the endothelial glycocalyx.


What are the Compounds in Arterosil-HP that Support the Endothelial Glycocalyx?

Arterosil HP is a patented formulation that contains a glycocalyx-supporting compound — rhamnan sulfate — derived from a rare green seaweed (Monostroma nitidum).

In addition, Arterosil HP contains an anti-oxidant rich fruit, vegetable and green tea extract blend that provides vascular benefits and supports the effects of rhamnan sulfate by reducing oxidative stress.

US Patent: “Methods to stabilize and reverse atherosclerotic lesions by sulfated polysaccaharides.”


More About the Functions of the Endothelial Glycocalyx

Important functions of the endothelial glycocalyx in vascular and micro-vascular health include:

  • Regulating vascular permeability and fluid balance
  • Supporting blood vessel health, regulating what gets through to the endothelium, providing a physical barrier against inadvertent adhesion of platelets and leukocytes to the vascular wall
  • Supporting healthy blood flow
  • Harboring beneficial antioxidants, coagulation factors and more
  • Triggering the production of nitric oxide (NO) in response to blood flow. NO is a natural gas the body produces that widens the blood vessels and has many important functions
  • Regulating coagulation (many of mediators of the coagulation pathway are buried inside the glycocalyx under normal physiological conditions)

The glycocalyx structure is so important, yet so delicate. It can be damaged by many common conditions, such as high blood glucose, oxidative stress, and inflammation.


Supporting the Endothelial Glycocalyx — A Major Breakthrough in Cardiovascular Medicine

“The arterial glycocalyx will likely be the next major breakthrough in cardiovascular medicine.

It is the first line of defense for the endothelium and its production of nitric oxide. The glycocalyx is like a protective “fur coat” for the endothelial cells that helps to prevent endothelial dysfunction.

The glycocalyx itself has many functions that may lower blood pressure, reduce coronary heart disease, decrease carotid plaque and lower stroke risk. We now have the ability to repair the glycocalyx with Arterosil.”

— Mark C. Houston, M.D., M.S., MSc, ABAARM, FAARM, FACP, FAHA, FASH, FACN, DABC, Author, Personalized and Precision Integrative Cardiovascular Medicine, Director, Hypertension Institute and Vascular Biology


The Endothelial Glycocalyx, Cardiovascular Injury and Inflammation

The endothelial glycocalyx is a microscopic anti-adhesive lining (“non-stick” lining) of the entire endothelium. (The endothelium is the tissue which forms a single layer of cells lining various organs and cavities of the body, especially the blood vessels, heart, and lymphatic vessels.)

Almost all cardiovascular challenges begins with injury to the vessels’ endothelium. The glycocalyx, a microscopic gel-like lining, naturally protects the endothelium.

When the glycocalyx is breached, cholesterol can adhere to, lodge under or penetrate the endothelial wall.

This initiates the inflammatory response that leads to plaque formation and thrombotic events. (The glycocalyx forms an interface between circulating blood and the rest of the vessel wall.)

The endothelial glycocalyx is exceptionally vulnerable to collapse through poor diet, disease, stress and aging. The glycocalyx plays a critical role in cardiovascular health.


How Arterosil HP Contributes to Healthy Vascular Function: 

  • Arterosil HP supports normal circulation*
  • Arterosil HP helps support normal artery function*
  • Arterosil HP helps maintain a healthy artery wall*
  • Arterosil supports a healthy heart*
  • Arterosil HP supports a strong and vital glycocalyx*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


Research on Rhamnam Sulfate, Research on Endothelial Glycocalyx

Research on Arterosil HP’s active ingredient — Rhamnan Sulfate from the seaweed Monostroma nitidum.
There are over 50 papers on PubMed that reference the rhamnan sulfate from Monostroma nitidum

Research on the Endothelial Glycocalyx — the fragile inner lining of the entire vascular system


Read more about Vascular Health and Why Blood Flow Matters.


The vascular system….60,000 miles of blood vessels — including arteries, veins and tiny capillaries — is essential to your total health.


COVID-19 is, in the end, an endothelial disease

Published in the European Heart Journal, August 2020, by Peter Libby and Thomas Lüscher

This essay explores the hypothesis that COVID-19, particularly in the later complicated stages, represents an endothelial disease.

Manufactured in the US by Calroy Health Sciences.


 

Arterosil HP – Ingredients

Serving Size:
2 Capsules
Servings Per Container: 30

Amount Per 2 Capsules:
Arterosil® HP
Proprietary Blend containing… 900mg
Green Seaweed (Monostroma sp.) extract
grape (seed and skin) extract
green tea (leaf) extract
grape pomace (fruit) extract
tomato (fruit)
carrot (root) juice,
bilberry (fruit),
broccoli (aerial parts)
green cabbage (leaf)
onion (bulb)
garlic (bulb)
grapefruit (fruit)
asparagus (stalk)
papaya (fruit)
pineapple (fruit)
strawberry (fruit)
apple (fruit)
apricot (fruit)
cherry (fruit)
orange (fruit)
blackcurrant (fruit)
olive (fruit)
cucumber (fruit)

Other Ingredients: Vegan capsule (hypromellose), microcrystalline cellulose, rice bran extract, peppermint (natural flavor), and rice hull concentrate.

Made without gluten, dairy or soy.
Vegan
Non-GMO

Supplement Facts Arterosil HP

 

Arterosil® is a registered trademark of Calroy Health Sciences, LLC.
US Patent. International Patents Pending


Arterosil HP – Suggested Use

Directions: Take 2 capsules daily, preferable one in the morning and one in the evening, with a meal, or as directed by your healthcare practitioner.

If you are pregnant, nursing or taking prescription medications, consult your physician prior to use.


 

Research on Rhamnan Sulfate, Key Arterosil HP Ingredient

There are over 50 papers on PubMed that reference the rhamnan sulfate from Monostroma nitidum.  

Below are some of the major studies, which are grouped under major headings, though the content of the studies often overlap. T

*The third-party information and links provided on this website are for educational and research purposes only, and are not intended to endorse, promote, or recommend any particular ingredient(s) or product(s).


Biological Activity Overview

  • Suzuki K, Terasawa M. Biological Activities of Rhamnan Sulfate Extract from the Green Algae Monostroma nitidum (Hitoegusa). Mar Drugs. 2020;18(4). doi:10.3390/md18040228
  • Saltiel D. The Effects of Rhamnan Sulfate From Monostroma Nitidum: A Vascular-Focused Literature Review. Altern Ther Health Med. 2023;29(4):24-26. Proquest Preview.

Endothelial Glycocalyx Repair

  • State Key Laboratory of Bioengineering, Institute of Process Engineering, Chinese Academy of Sciences. Rhamnan Sulfate in a Proprietary Extract of Monostroma Nitidum Regenerates a Compromised Endothelial Glycocalyx Shed Caused by High Glucose. Data provided by researchers. 2023, March. Manuscript.

Blood Vessel Wall

  • Patil NP, Gómez-Hernández A, Zhang F, et al. Rhamnan sulfate reduces atherosclerotic plaque formation and vascular inflammation. Biomaterials. 2022;291:121865. doi:10.1016/j.biomaterials.2022.121865

Blood Pressure

  • Houston, Mark. An Open-Label, Single-Arm, Pilot Study to Evaluate the Effect of a Proprietary Rhamnan Sulfate (RS) Containing Dietary Supplement on Blood Pressure among Hypertensive Individuals. 2023; Mar. Manuscript.

Characterization & Hypoglycemic Activity

  • Cui JF, Ye H, Zhu YJ, Li YP, Wang JF, Wang P. Characterization and Hypoglycemic Activity of a Rhamnan-Type Sulfated Polysaccharide Derivative. Mar Drugs. 2019;17(1):E21. doi:10.3390/md17010021.

LDL Permeability

  • Cancel LM, Tarbell JM. Rhamnan sulfate enhances the endothelial glycocalyx and decreases the LDL permeability of human coronary artery endothelial cells in vitro. The FASEB Journal. 2013;27(S1):896.3-896.3. doi:10.1096/fasebj.27.1_supplement.896.3.

Anti-Inflammatory Activity

  • Terasawa M, Hiramoto K, Uchida R, Suzuki K. Anti-Inflammatory Activity of Orally Administered Monostroma nitidum Rhamnan Sulfate against Lipopolysaccharide-Induced Damage to Mouse Organs and Vascular Endothelium. Mar Drugs. 2022;20(2):121. doi:10.3390/md20020121
  • Okamoto T, Akita N, Terasawa M, Hayashi T, Suzuki K. Rhamnan sulfate extracted from Monostroma nitidum attenuates blood coagulation and inflammation of vascular endothelial cells. J Nat Med. 2019;73(3):614-619. doi:10.1007/s11418-019-01289-5
  • Patil NP, Gómez-Hernández A, Zhang F, et al. Rhamnan sulfate reduces atherosclerotic plaque formation and vascular inflammation. Biomaterials. 2022;291:121865. doi:10.1016/j.biomaterials.2022.121865

Hepatic Steatosis

  • Zang L, Shimada Y, Tanaka T, Nishimura N. Rhamnan sulphate from Monostroma nitidum attenuates hepatic steatosis by suppressing lipogenesis in a diet-induced obesity zebrafish model. Journal of Functional Foods. 2015;17:364-370. doi:10.1016/j.jff.2015.05.041

Anti-Thrombin Activity

  • Harada N, Maeda M. Chemical structure of antithrombin-active Rhamnan sulfate from Monostroma nitidum. Biosci Biotechnol Biochem. 1998;62(9):1647-1652. doi:10.1271/bbb.62.1647
  • Liu X, Du P, Liu X, et al. Anticoagulant Properties of a Green Algal Rhamnan-type Sulfated Polysaccharide and Its Low-molecular-weight Fragments Prepared by Mild Acid Degradation. Mar Drugs. 2018;16(11):E445. doi:10.3390/md16110445
  • Liu X, Wang S, Cao S, et al. Structural Characteristics and Anticoagulant Property In Vitro and In Vivo of a Seaweed Sulfated Rhamnan. Marine Drugs. 2018;16(7):243. doi:10.3390/md16070243
  • Okamoto T, Akita N, Terasawa M, Hayashi T, Suzuki K. Rhamnan sulfate extracted from Monostroma nitidum attenuates blood coagulation and inflammation of vascular endothelial cells. J Nat Med. 2019;73(3):614-619. doi:10.1007/s11418-019-01289-5

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