Calocurb – GLP-1 Activator, Amarasate® Natural Hops Extract
$89.99
GLP-1 Activator
Pre-meal appetite management support supplement
Plant-based — Natural Hops Extract
Clinically shown to reduce calorie intake over meals and snacking
Starts to work in one hour
90 Plant-based Capsules
Contains NO: sugar, starch, yeast, wheat, gluten, soy, milk, eggs, shellfish, fish, peanuts, tree nuts. No artificial colors, flavors or preservatives
GMO free
100% Plant based ingredients
From Calocurb
Product Description
Calocurb with Amarasate® – Pre-meal Appetite Management
Clinically Shown to Reduce Calorie Intake Over Meals and Snacking:
Natural GLP-1 Activator from Bitter Hops Extract (Amarasate®)
Calocurb has been clinically shown to:
- Reduce caloric intake by an average of 18% (meaning smaller meals and less snacking)
- Reduce feelings of hunger by up to 30%
- Reduce feelings of cravings by up to 40%
- Increase GLP-1 and CCK at 6x base levels lasting for four hours
Take Calocurb one hour before meals to naturally activate your own anti-hunger hormones and help support management of your appetite.
How Calocurb Amarasate® Hops Extract Works
Bitter compounds in Amarasate hops extract stimulate the stomach tastebuds to release a natural blend of appetite suppressing hormones that activate sensory cells in the upper intestine.
Sensing bitterness, these cells release your own natural compounds (like GLP-1 CCK, PYY) which slow down the gastric emptying rate and send “stop eating” signals from the stomach to the brain. The signals decrease appetite and dissipate food cravings.
Calocurb boosts your own natural hormones to help manage your hunger and energy intake and help you feel full faster.
Calocurb activates “the bitter brake,” mimicking a natural, evolution response to bitter foods to create a feeling of fullness.
Is Calocurb for You?
Taking Calocurb for the first time may cause a mild laxative effect which should cease after 24-72 hours of use. That’s why the suggested dose is to build up slowly over five days, after which the digestive issues usually pass.
Of course there are always exceptions…Calocurb should not be taken by individuals that have any form of gastrointestinal inflammation or inflammatory bowel disease, such as Crohn’s or ulcerative colitis. Calocurb is also not indicated for patients with type 1 diabetes mellitus.
Read Suggested Use Tab for more information.
Manufactured in the USA with local and imported ingredients. Extraction from freshly picked hops bt CO2, chemical free extraction.
Distributed by Calocurb
References:
An extract of hops (Humulus lupulus L.) modulates gut peptide hormone secretion and reduces energy intake in healthy-weight men: a randomized, crossover clinical trial
Gastrointestinal Delivery of Bitter Hops Extract Reduces Appetite and Food Cravings in Healthy Adult Women Undergoing Acute Fasting
New Zealand Bitter Hops Extract Reduces Hunger During a 24 h Water Only Fast
Calocurb – Ingredients
Each capsule contains only 3 natural ingredients – 125 mg of natural New Zealand Amarasate® hops extract, rosemary extract and vegetable oil.
Contains NO: sugar, starch, yeast, wheat, gluten, soy, milk, eggs, shellfish, fish, peanuts, tree nuts.
No artificial colors, flavors or preservatives.
Kosher certified.
Calocurb – Suggested Use
Serving size: Two (2) capsules
You can tailor your dosage daily, to take between 1-4 capsules.
Take the capsule(s) with a glass of water, one hour (to 1-1/2 hours) prior to a meal, on an empty stomach.
[This makes sure that the capsule gets through the stomach and disintegrates in the upper duodenum. There the active ingredient Amarasate will activate receptor cells on the enteroendocrine cells of the digestive tract. If there is food in the stomach, this can delay the passage.]
Days One & Two: 1 capsule per day for the first 48 hours.
Days Three & Four: Take 1 capsule, twice daily at least 4 hours apart.
Day Five: Take 2 capsules, twice daily at least 4 hours apart.
Do not open the capsule.
Do not exceed 4 capsules per day.
NOTE: Basically, you are building up to two capsules twice daily, one hour to one and one half hour before meals. Some clients like to take it at 11 am and 5 pm. Others prefer first thing in the morning (7 or 8 am) and then again later in the day.
However, dosing may be tailored depending on patient sensitivity to bitterness and to increased susceptibility to mild GI side effects. For sensitive individuals, build up to 1 capsule, twice a day, 1 hour to and 1-1/2 half hours before meals, on an empty stomach.
Taking Calocurb for the first time may cause a mild laxative effect which should cease after 24-72 hours of use. This effect is based on the presence and activity of the cells responding to the Amarasate stimulation which is why it is advised to build up the dose over five days. The body typically gets used to the increased GLP-1/CCK levels and the digestive issues pass. If someone’s digestive tract is more sensitive, they can stay at one capsule prior to lunch and one capsule prior to dinner.
Who should not take Calocurb? Calocurb should not be taken by individuals that have any form of gastrointestinal inflammation or inflammatory bowel disease, such as Crohn’s or ulcerative colitis. Calocurb is not indicated for patients with type 1 diabetes mellitus.
Store below 25 degrees C (77 degrees F) in a cool, dry place. Keep out of reach of children
By Calocurb
Calocurb – FAQs
From the Manufacturer:
How does Calocurb compare to the latest anti-obesity medication in terms of its Mechanism of Action?
A. Amarasate® stimulates the body’s own release of GLP-1 and CCK to 6 times baseline levels within an hour, lasting up to 4 hours. If Calocurb is taken one hour before a meal, the natural response to eating a meal will follow, with an enhanced appetite suppression that is slightly prolonged but gradually tapers off. This allows individuals to achieve a harmonious balance between their gut and brain appetite function. Semaglutide injectables elevate exogenous GLP-1 levels to super-physiological concentration, leading to long-lasting effects attributable to their resistance to breakdown, without adhering to the natural rhythm of hormone release.
Has a weight-loss study been conducted using Calocurb?
A. A six-month weight loss study with a three-month flow-up period will begin in 2024 to assess the long-term effectiveness of Calocurb as a weight loss supplement. This study is designed as a randomized double-blind, crossover clinical trial in 150 adult men and women with a BMI>30. It is worth noting that the GLP-1 system, which is targeted by Calocurb, has shown effectiveness for weight management.
Does Amarasate have an effect on glucose levels?
A. The 2022 study by Walker et at. demonstrated an acute improvement in post meal glucose levels, despite no increases in insulin release. This is likely due to the gut hormones GLP-1 and CCK delaying the rate of gastric emptying resulting in slower glucose absorption into the blood. Secondly, GLP-1 can also potentiate the release of insulin relative to glucose absorption, hence improving glucose clearance from the blood.
What is the bioavailability of the Amarasate extract used in Calocurb?
A. Animal studies have shown limited to nil absorption into the bloodstream; 99% of ingested hops are degraded in the lower bowel. This low bioavailability reduces the chances of interaction with other medications which are being metabolized through the liver or kidneys.
How quickly does Calocurb show its effects on appetite, and how long do they last?
A. The effects of Calocurb are typically observed within an hour of consumption. Calocurb users report residual satiety effects for up to four hours.
Bitter extracts are sometimes used to stimulate appetite. Why does Amarasate not do this?
A. The delayed release of Amarasate bitter extract in the upper duodenum stimulates the activation of TAS2R receptors on enteroendocrine cells to release GLP-1, CCK and PYY (appetite suppressing hormones). The delayed release capsule avoids the gastric environment of the stomach which when stimulated by bitterness extract, may stimulate an appetite-promoting effect.
Can Calocurb cause a sedative effect?
A. Hops has been historically used as a mild sedative. Supercritical CO2 extraction removes almost all of the organic material from the hops including the prenylflavonoids (e.g. xanthohumols). Research shows that the sedative effect is due to the organic materials (e.g xanthohumols, myrcenols and alpha and beta acid derivates) which are removed to negligible levels during the supercritical CO2 extraction to develop Amarasate.
Amarasate is an extract of hops, can it have an estrogenic effect?
A. CO2 supercritical extraction removes the majority of organic materials including the prenylflavonoids (xanthohumols. isoxanthohumol and 8-PN), leaving a purified hops extract, predominantly alpha acid (humulones) and beta acid (lupulones).
