Vascanox HP – Nitric Oxide Support (from makers of Arterosil HP)

$69.00

Nitric Oxide Support for Up to 24 Hours

Proprietary Blend of Extracts – black garlic, beetroot, black currant, bilberry, raspberry extract, blue honeysuckle berry, and blueberry, with vitamins and minerals

From Calroy Sciences, makers of Arterosil HP

60 vegan Capsules

Each 60-capsule bottle is a 1-month supply at recommended dosing levels

Excellent companion product for Arterosil HP

Free Shipping within US

Product Description

Vascanox HP – Nitric Oxide Support

Supports Production, Storage, Release of Nitric Oxide

Vascanox HP is a breakthrough product providing nitric oxide support for up to 24 hours with a single dose (as shown in a recent study, open-label IRB approved using N.O. test strips to measure nitric oxide). Vascanox HP supports the natural production, storage, and release of nitric oxide through multiple pathways.

Nitric oxide is a signaling messenger molecule that is produced in the body through both nitric oxide synthase (NOS) pathway and nitrate-nitric oxide pathway.

Nitric oxide signals blood vessels to widen which in turn allows greater blood flow to tissues like the heart and brain. Blood vessels are supposed to be able to dilate and constrict as needed.

Vascanox HP is a great companion product to Arterosil-HP. (Arterosil-HP is a foundational supplement that supports the endothelial glycocalyx, the fragile inner lining of the entire vascular system. The endothelial glycocalyx supports and regulates the entire vascular system, key to good blood flow, normal blood pressure and healthy arteries.)

Healthy vascular function is essential to every organ and system in the body. The endothelial glycocalyx lines every artery and vessel inside the body.


Nitric Oxide Regulates Blood Pressure, Transmits Signals Between Neurons, Suppresses Pathogens

Nitric Oxide has great physiological importance.

“Nitric oxide is an unusual messenger molecule with many physiologic roles, in the cardiovascular, neurologic and immune systems. It mediates blood vessel relaxation, neurotransmission and pathogen {bacteria and parasites} suppression.”

Physiological and Clinical Importance of Nitric Oxide


Nitric Oxide Production Naturally Declines with Aging

The natural decline of nitric oxide production can contribute to dysfunction of inner arterial walls. Arterial stiffness contributes to high blood pressure and inflammation in the arteries, risk factors for cardiovascular disease.


What’s in Vascanox HP?

Vascanox HP contains a proprietary blend of black garlic extract, beetroot extract, black currant extract, bilberry extract, raspberry extract, blue honeysuckle berry extract, and blueberry extract. It also contains vitamin C, vitamin D, Thiamine and vitamin B12, as well as several minerals. See ingredients tab for Supplement Facts.

 

Vascanox HP – Ingredients

Vascanox HP Supplement Facts

Vascanax HP – Suggested Use

Take 2 capsules in the morning with a meal, or as directed by your healthcare practitioner.

If you are pregnant, nursing or taking prescription medications, consult your healthcare practitioner prior to use.

Does not contain: gluten, milk, dairy, soy, eggs, fish, crustacean shellfish, tree nuts, peanuts, sesame seeds, mustard, lupine or mollusks.


Research on Nitric Oxide and Vascular System

There are over 50,000 papers on PubMed that discuss nitric oxide and the vascular system. 

*The third-party information and links provided on this website are for educational and research purposes only, and are not intended to endorse, promote, or recommend any particular ingredient(s) or product(s).

Product-specific study

  • Houston, Mark. An Open-Label Study to Evaluate the Safety and Efficacy of a Novel Oral Nitric Oxide Supplement. 2023; Jan. Manuscript.

Vascular health and nitric oxide

  • Förstermann Ulrich, Münzel Thomas. Endothelial Nitric Oxide Synthase in Vascular Disease. Circulation. 2006;113(13):1708-1714. doi:10.1161/CIRCULATIONAHA.105.602532
  • Forte M, Conti V, Damato A, et al. Targeting Nitric Oxide with Natural Derived Compounds as a Therapeutic Strategy in Vascular Diseases. Oxidative Medicine and Cellular Longevity. 2016;2016:e7364138. doi:10.1155/2016/7364138
  • Infante T, Costa D, Napoli C. Novel Insights Regarding Nitric Oxide and Cardiovascular Diseases. Angiology. 2021;72(5):411-425. doi:10.1177/0003319720979243
  • Levine AB, Punihaole D, Levine TB. Characterization of the Role of Nitric Oxide and Its Clinical Applications. Cardiology. 2012;122(1):55-68. doi:10.1159/000338150
  • Lima B, Forrester MT, Hess DT, Stamler JS. S-Nitrosylation in Cardiovascular Signaling. Circulation Research. 2010;106(4):633-646. doi:10.1161/CIRCRESAHA.109.207381
  • Sverdlov AL, Ngo DTM, Chan WPA, Chirkov YY, Horowitz JD. Aging of the Nitric Oxide System: Are We as Old as Our NO? J Am Heart Assoc. 2014;3(4):e000973. doi:10.1161/JAHA.114.000973
  • Toda N, Ayajiki K, Okamura T. Nitric oxide and penile erectile function. Pharmacol Ther. 2005;106(2):233-266. doi:10.1016/j.pharmthera.2004.11.011
  • Torregrossa AC, Aranke M, Bryan NS. Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly. J Geriatr Cardiol. 2011;8(4):230-242. doi:10.3724/SP.J.1263.2011.00230
  • Tran N, Garcia T, Aniqa M, Ali S, Ally A, Nauli S. Endothelial Nitric Oxide Synthase (eNOS) and the Cardiovascular System: in Physiology and in Disease States. Am J Biomed Sci Res. 2022;15(2):153-177. 

Nitric Oxide Production

  • Alvares TS, Conte-Junior CA, Silva JT, Paschoalin VMF. Acute L-Arginine supplementation does not increase nitric oxide production in healthy subjects. Nutr Metab (Lond). 2012;9:54. doi:10.1186/1743-7075-9-54
  • Bartosch AMW, Mathews R, Tarbell JM. Endothelial Glycocalyx-Mediated Nitric Oxide Production in Response to Selective AFM Pulling. Biophys J. 2017;113(1):101-108. doi:10.1016/j.bpj.2017.05.033
  • Dragovich MA, Chester D, Fu BM, et al. Mechanotransduction of the endothelial glycocalyx mediates nitric oxide production through activation of TRP channels. American Journal of Physiology-Cell Physiology. 2016;311(6):C846-C853. doi:10.1152/ajpcell.00288.2015
  • Förstermann Ulrich, Münzel Thomas. Endothelial Nitric Oxide Synthase in Vascular Disease. Circulation. 2006;113(13):1708-1714. doi:10.1161/CIRCULATIONAHA.105.602532
  • Ghimire K, Altmann HM, Straub AC, Isenberg JS. Nitric oxide: what’s new to NO? Am J Physiol Cell Physiol. 2017;312(3):C254-C262. doi:10.1152/ajpcell.00315.2016
  • Gouverneur M, Berg B, Nieuwdorp M, Stroes E, Vink H. Vasculoprotective properties of the endothelial glycocalyx: effects of fluid shear stress. J Intern Med. 2006;259(4):393-400. doi:10.1111/j.1365-2796.2006.01625.x
  • Kurzelewski M, Czarnowska E, Beresewicz A. Superoxide- and nitric oxide-derived species mediate endothelial dysfunction, endothelial glycocalyx disruption, and enhanced neutrophil adhesion in the post-ischemic guinea-pig heart. J Physiol Pharmacol. 2005;56(2):163-178.
  • Lundberg JO, Weitzberg E, Gladwin MT. The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov. 2008;7(2):156-167. doi:10.1038/nrd2466
  • Tejero J, Shiva S, Gladwin MT. Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation. Physiological Reviews. 2019;99(1):311-379. doi:10.1152/physrev.00036.2017
  • Torregrossa AC, Aranke M, Bryan NS. Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly. J Geriatr Cardiol. 2011;8(4):230-242. doi:10.3724/SP.J.1263.2011.00230

Synergy with hydrogen sulfide

  • Altaany Z, Ju Y, Yang G, Wang R. The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide. Sci Signal. 2014;7(342):ra87. doi:10.1126/scisignal.2005478
  • Bailey TS, Zakharov LN, Pluth MD. Understanding Hydrogen Sulfide Storage: Probing Conditions for Sulfide Release from Hydrodisulfides. J Am Chem Soc. 2014;136(30):10573-10576. doi:10.1021/ja505371z
  • Blackwood EA, Glembotski CC. Hydrogen sulfide: the gas that fuels longevity. The Journal of Cardiovascular Aging. 2022;2(3):26. doi:10.20517/jca.2022.16
  • Bryan NS, Lefer DJ. Update on Gaseous Signaling Molecules Nitric Oxide and Hydrogen Sulfide: Strategies to Capture their Functional Activity for Human Therapeutics. Mol Pharmacol. 2019;96(1):109-114. doi:10.1124/mol.118.113910
  • Cirino G, Vellecco V, Bucci M. Nitric oxide and hydrogen sulfide: the gasotransmitter paradigm of the vascular system. British Journal of Pharmacology. 2017;174(22):4021-4031. doi:10.1111/bph.13815
  • Coletta C, Papapetropoulos A, Erdelyi K, et al. Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation. PNAS. 2012;109(23):9161-9166. doi:10.1073/pnas.1202916109
  • Gheibi S, Jeddi S, Kashfi K, Ghasemi A. Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension. Biochem Pharmacol. 2018;149:42-59. doi:10.1016/j.bcp.2018.01.017
  • Giuffrè A, Vicente JB. Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology. Oxidative Medicine and Cellular Longevity. 2018;2018:e6290931. doi:10.1155/2018/6290931
  • Guo W, Cheng Z yu, Zhu Y zhun. Hydrogen sulfide and translational medicine. Acta Pharmacol Sin. 2013;34(10):1284-1291. doi:10.1038/aps.2013.127
  • Hosoki R, Matsuki N, Kimura H. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem Biophys Res Commun. 1997;237(3):527-531. doi:10.1006/bbrc.1997.6878
  • Kevil CG, Patel RP. S-nitrosothiol biology and therapeutic potential in metabolic disease. Curr Opin Investig Drugs. 2010;11(10):1127-1134.
  • Kolluru GK, Shackelford RE, Shen X, Dominic P, Kevil CG. Sulfide regulation of cardiovascular function in health and disease. Nat Rev Cardiol. Published online August 5, 2022:1-17. doi:10.1038/s41569-022-00741-6
  • Kuschman HP, Palczewski MB, Thomas DD. Nitric oxide and hydrogen sulfide: Sibling rivalry in the family of epigenetic regulators. Free Radical Biology and Medicine. 2021;170:34-43. doi:10.1016/j.freeradbiomed.2021.01.010
  • Lin Y, Chen Y, Zhu N, Zhao S, Fan J, Liu E. Hydrogen sulfide inhibits development of atherosclerosis through up-regulating protein S-nitrosylation. Biomedicine & Pharmacotherapy. 2016;83:466-476. doi:10.1016/j.biopha.2016.07.003
  • Lv B, Chen S, Tang C, Jin H, Du J, Huang Y. Hydrogen sulfide and vascular regulation – An update. Journal of Advanced Research. 2021;27:85-97. doi:10.1016/j.jare.2020.05.007
  • Murphy B, Bhattacharya R, Mukherjee P. Hydrogen sulfide signaling in mitochondria and disease. FASEB J. 2019;33(12):13098-13125. doi:10.1096/fj.201901304R
  • Mys LA, Strutynska NA, Goshovska YV, Sagach VF. Stimulation of the endogenous hydrogen sulfide synthesis suppresses oxidative-nitrosative stress and restores endothelial-dependent vasorelaxation in old rats. Can J Physiol Pharmacol. 2020;98(5):275-281. doi:10.1139/cjpp-2019-0411
  • Nagpure BV, Bian JS. Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular System. Oxidative Medicine and Cellular Longevity. 2015;2016:e6904327. doi:10.1155/2016/6904327
  • Pan LL, Qin M, Liu XH, Zhu YZ. The Role of Hydrogen Sulfide on Cardiovascular Homeostasis: An Overview with Update on Immunomodulation. Front Pharmacol. 2017;8. doi:10.3389/fphar.2017.00686
  • Polhemus David J., Lefer David J. Emergence of Hydrogen Sulfide as an Endogenous Gaseous Signaling Molecule in Cardiovascular Disease. Circulation Research. 2014;114(4):730-737. doi:10.1161/CIRCRESAHA.114.300505
  • Rajendran S, Shen X, Glawe J, Kolluru GK, Kevil CG. Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling. Compr Physiol. 2019;9(3):1213-1247. doi:10.1002/cphy.c180026
  • Szabo C. Hydrogen sulfide, an enhancer of vascular nitric oxide signaling: mechanisms and implications. Am J Physiol Cell Physiol. 2017;312(1):C3-C15. doi:10.1152/ajpcell.00282.2016
  • Wallace JL, Wang R. Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter. Nat Rev Drug Discov. 2015;14(5):329-345. doi:10.1038/nrd4433
  • Wu D, Hu Q, Zhu D. An Update on Hydrogen Sulfide and Nitric Oxide Interactions in the Cardiovascular System. Oxid Med Cell Longev. 2018;2018:4579140. doi:10.1155/2018/4579140

Exercise performance

  • Bailey SJ, Winyard P, Vanhatalo A, et al. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol (1985). 2009;107(4):1144-1155. doi:10.1152/japplphysiol.00722.2009
  • Bescós R, Sureda A, Tur JA, Pons A. The effect of nitric-oxide-related supplements on human performance. Sports Med. 2012;42(2):99-117. doi:10.2165/11596860-000000000-00000
  • Bond H, Morton L, Braakhuis AJ. Dietary nitrate supplementation improves rowing performance in well-trained rowers. Int J Sport Nutr Exerc Metab. 2012;22(4):251-256. doi:10.1123/ijsnem.22.4.251
  • Cermak NM, Gibala MJ, van Loon LJC. Nitrate supplementation’s improvement of 10-km time-trial performance in trained cyclists. Int J Sport Nutr Exerc Metab. 2012;22(1):64-71. doi:10.1123/ijsnem.22.1.64
  • Coggan AR, Baranauskas MN, Hinrichs RJ, Liu Z, Carter SJ. Effect of dietary nitrate on human muscle power: a systematic review and individual participant data meta-analysis. J Int Soc Sports Nutr. 2021;18(1):66. doi:10.1186/s12970-021-00463-z
  • Hoon MW, Hopkins WG, Jones AM, et al. Nitrate supplementation and high-intensity performance in competitive cyclists. Appl Physiol Nutr Metab. 2014;39(9):1043-1049. doi:10.1139/apnm-2013-0574
  • Lansley KE, Winyard PG, Fulford J, et al. Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study. J Appl Physiol (1985). 2011;110(3):591-600. doi:10.1152/japplphysiol.01070.2010
  • Muggeridge DJ, Howe CCF, Spendiff O, Pedlar C, James PE, Easton C. A single dose of beetroot juice enhances cycling performance in simulated altitude. Med Sci Sports Exerc. 2014;46(1):143-150. doi:10.1249/MSS.0b013e3182a1dc51
  • Pinna M, Roberto S, Milia R, et al. Effect of Beetroot Juice Supplementation on Aerobic Response during Swimming. Nutrients. 2014;6(2):605-615. doi:10.3390/nu6020605
  • Sj B, J F, A V, et al. Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. Journal of applied physiology (Bethesda, Md : 1985). 2010;109(1). doi:10.1152/japplphysiol.00046.2010
  • Vanhatalo A, Bailey SJ, Blackwell JR, et al. Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol. 2010;299(4):R1121-1131. doi:10.1152/ajpregu.00206.2010
  • Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-336. doi:10.1152/japplphysiol.00372.2013

 


 

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