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Biochemistry: Why DAO Can Help Histamine Intolerance

Biochemistry: Why DAO Can Help Histamine Intolerance


Histamine Biochemistry and DAO

Look at the histamine pathways and you’ll see why the supplement DAO (diamine-oxidase) helps many people with their symptoms of histamine intolerance!

The image shows the biochemistry of how histamine gets degraded in the body. The breakdown of histamine is through two pathways:

  1. via the enzyme DAO in the gut, or
  2. via the enzyme HNMT in the rest of the body.

Some people just don’t make enough of their own DAO enzyme.

This could be due to a genetic SNP that they have.

Or, it could be that their requirement for DAO may be very high due to the fact that they eat a diet high in histamines or their body releases excessive histamines.

A DAO supplement (Umbrellux-DAO) supports the clearing of histamines from foods, or from foods (and medicines) that trigger the release of histamines.

(The DAO pathway also requires nutritional cofactors – iron, B12, B6, copper and Vitamin C.)


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